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The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis

Although the zinc finger transcription factor Wt1 has been linked to female fertility, its precise role in this process has not yet been understood. We have sequenced the WT1 exons in a panel of patients with idiopathic infertility and have identified a missense mutation in WT1 in one patient out of...

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Bibliographische Detailangaben
Hauptverfasser: Nathan, Abinaya (VerfasserIn) , Holschbach, Verena (VerfasserIn) , Toth, Bettina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 March 2017
In: Human molecular genetics
Year: 2017, Jahrgang: 26, Heft: 9, Pages: 1694-1705
ISSN:1460-2083
DOI:10.1093/hmg/ddx075
Online-Zugang:Resolving-System, Volltext: http://dx.doi.org/10.1093/hmg/ddx075
Verlag, Volltext: https://academic.oup.com/hmg/article/26/9/1694/3059288
Volltext
Verfasserangaben:Abinaya Nathan, Peter Reinhardt, Dagmar Kruspe, Tjard Jörß, Marco Groth, Hendrik Nolte, Andreas Habenicht, Jörg Herrmann, Verena Holschbach, Bettina Toth, Marcus Krüger, Zhao-Qi Wang, Matthias Platzer, Christoph Englert
Beschreibung
Zusammenfassung:Although the zinc finger transcription factor Wt1 has been linked to female fertility, its precise role in this process has not yet been understood. We have sequenced the WT1 exons in a panel of patients with idiopathic infertility and have identified a missense mutation in WT1 in one patient out of eight. This mutation leads to an amino acid change within the zinc finger domain and results in reduced DNA binding.
Beschreibung:Gesehen am 27.07.2018
Beschreibung:Online Resource
ISSN:1460-2083
DOI:10.1093/hmg/ddx075

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