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S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-[kappa]B signaling

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The extracellular heterodimeric protein S100A8/A9 activates the innate immune system through activation of the receptor of advanced glycation end products (RAGE) and Toll-like receptors. As activation of RAGE has recently been associated with sustained myocardial inflammation and heart failure (HF)...

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Main Authors: Volz, Hans Christian (Author) , Laohachewin, Danai (Author) , Seidel, Cathrin (Author) , Lasitschka, Felix (Author) , Keilbach, Kirsten (Author) , Wienbrandt, Alexandra (Author) , Andrassy, Joachim (Author) , Bierhaus, Angelika (Author) , Kaya, Ziya (Author) , Katus, Hugo (Author) , Andrassy, Martin (Author)
Format: Article (Journal)
Language:English
Published: 10 February 2012
In: Basic research in cardiology
Year: 2012, Volume: 107
ISSN:1435-1803
DOI:10.1007/s00395-012-0250-z
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00395-012-0250-z
Verlag, Volltext: https://link.springer.com/article/10.1007/s00395-012-0250-z
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Author Notes:H. Christian Volz, Danai Laohachewin, Cathrin Seidel, Felix Lasitschka, Kirsten Keilbach, Alexandra R. Wienbrandt, Joachim Andrassy, Angelika Bierhaus, Ziya Kaya, Hugo A. Katus, Martin Andrassy
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