Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation
The activity of some small GTPases is regulated by covalent transamidation of serotonin (5-hydropxytryptamien) to glutamine residues of the enzymes. This process is mediated by transglutaminase (TGase) and is termed “serotonylation”. In addition, serotonylation of neural proteins and proteins of the...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 July 2012
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| In: |
FEBS letters
Year: 2012, Jahrgang: 586, Heft: 19, Pages: 3421-3428 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2012.07.062 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.febslet.2012.07.062 Verlag, Volltext: http://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2012.07.062 
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| Verfasserangaben: | René Hummerich, Jörg-Oliver Thumfart, Peter Findeisen, Dusan Bartsch, Patrick Schloss |
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| 245 | 1 | 0 | |a Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin |b evidence for a general mechanism of monoaminylation |c René Hummerich, Jörg-Oliver Thumfart, Peter Findeisen, Dusan Bartsch, Patrick Schloss |
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| 520 | |a The activity of some small GTPases is regulated by covalent transamidation of serotonin (5-hydropxytryptamien) to glutamine residues of the enzymes. This process is mediated by transglutaminase (TGase) and is termed “serotonylation”. In addition, serotonylation of neural proteins and proteins of the extracellular matrix such as fibronectin has been demonstrated. Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase. All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated “monoaminylation”. | ||
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