Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide
Therapy-related acute promyelocytic leukemia (t-APL) is relatively rare, with limited data on outcome after treatment with arsenic trioxide (ATO) compared to standard intensive chemotherapy (CTX). We evaluated 103 adult t-APL patients undergoing treatment with all-trans retinoic acid (ATRA) alone (n...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 April 2017
|
| In: |
Leukemia
Year: 2017, Jahrgang: 31, Heft: 11, Pages: 2347-2354 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2017.92 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/leu.2017.92 Verlag, Volltext: https://www.nature.com/articles/leu201792 
|
| Verfasserangaben: | S. Kayser, J. Krzykalla, M.A. Elliott, K. Norsworthy, P. Gonzales, R.K. Hills, M.R. Baer, Z. Ráčil, J. Mayer, J. Novak, P. Žák, T. Szotkowski, D. Grimwade, N.H. Russell, R.B. Walter, E H. Estey, J. Westermann, M. Görner, A. Benner, A. Krämer, B.D. Smith, A.K. Burnett, C. Thiede, C. Röllig, A.D. Ho, G. Ehninger, R.F. Schlenk, M.S. Tallman, M.J. Levis and U. Platzbecker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1578060389 | ||
| 003 | DE-627 | ||
| 005 | 20220814203331.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180730s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/leu.2017.92 |2 doi | |
| 035 | |a (DE-627)1578060389 | ||
| 035 | |a (DE-576)508060389 | ||
| 035 | |a (DE-599)BSZ508060389 | ||
| 035 | |a (OCoLC)1341014652 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kayser, Sabine |d 1979- |e VerfasserIn |0 (DE-588)138694923 |0 (DE-627)605256233 |0 (DE-576)30778813X |4 aut | |
| 245 | 1 | 0 | |a Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide |c S. Kayser, J. Krzykalla, M.A. Elliott, K. Norsworthy, P. Gonzales, R.K. Hills, M.R. Baer, Z. Ráčil, J. Mayer, J. Novak, P. Žák, T. Szotkowski, D. Grimwade, N.H. Russell, R.B. Walter, E H. Estey, J. Westermann, M. Görner, A. Benner, A. Krämer, B.D. Smith, A.K. Burnett, C. Thiede, C. Röllig, A.D. Ho, G. Ehninger, R.F. Schlenk, M.S. Tallman, M.J. Levis and U. Platzbecker |
| 264 | 1 | |c 18 April 2017 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.07.2018 | ||
| 520 | |a Therapy-related acute promyelocytic leukemia (t-APL) is relatively rare, with limited data on outcome after treatment with arsenic trioxide (ATO) compared to standard intensive chemotherapy (CTX). We evaluated 103 adult t-APL patients undergoing treatment with all-trans retinoic acid (ATRA) alone (n=7) or in combination with ATO (n=24), CTX (n=53), or both (n=19). Complete remissions were achieved after induction therapy in 57% with ATRA, 100% with ATO/ATRA, 78% with CTX/ATRA, and 95% with CTX/ATO/ATRA. Early death rates were 43% for ATRA, 0% for ATO/ATRA, 12% for CTX/ATRA and 5% for CTX/ATO/ATRA. Three patients relapsed, two developed therapy-related acute myeloid leukemia and 13 died in remission including seven patients with recurrence of the prior malignancy. Median follow-up for survival was 3.7 years. None of the patients treated with ATRA alone survived beyond one year. Event-free survival was significantly higher after ATO-based therapy (95%, 95% CI, 82-99%) as compared to CTX/ATRA (78%, 95% CI, 64-87%; P=0.042), if deaths due to recurrence of the prior malignancy were censored. The estimated 2-year overall survival in intensively treated patients was 88% (95% CI, 80-93%) without difference according to treatment (P=0.47). ATO when added to ATRA or CTX/ATRA is feasible and leads to better outcomes as compared to CTX/ATRA in t-APL. | ||
| 700 | 1 | |a Benner, Axel |d 1959- |e VerfasserIn |0 (DE-588)106584686X |0 (DE-627)81687221X |0 (DE-576)425536602 |4 aut | |
| 700 | 1 | |a Krämer, Alwin |e VerfasserIn |0 (DE-588)1067780025 |0 (DE-627)819183431 |0 (DE-576)426900820 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Schlenk, Richard Friedrich |d 1965- |e VerfasserIn |0 (DE-588)129025380 |0 (DE-627)387778004 |0 (DE-576)297454102 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 31(2017), 11, Seite 2347-2354 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide |
| 773 | 1 | 8 | |g volume:31 |g year:2017 |g number:11 |g pages:2347-2354 |g extent:8 |a Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/leu.2017.92 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/leu201792 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180730 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 129025380 |a Schlenk, Richard Friedrich |m 129025380:Schlenk, Richard Friedrich |d 50000 |e 50000PS129025380 |k 0/50000/ |p 27 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 25 | ||
| 998 | |g 1067780025 |a Krämer, Alwin |m 1067780025:Krämer, Alwin |d 910000 |d 910100 |e 910000PK1067780025 |e 910100PK1067780025 |k 0/910000/ |k 1/910000/910100/ |p 20 | ||
| 998 | |g 106584686X |a Benner, Axel |m 106584686X:Benner, Axel |d 50000 |e 50000PB106584686X |k 0/50000/ |p 19 | ||
| 998 | |g 138694923 |a Kayser, Sabine |m 138694923:Kayser, Sabine |d 910000 |d 910100 |e 910000PK138694923 |e 910100PK138694923 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1578060389 |e 3019732557 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"18 April 2017"}],"physDesc":[{"extent":"8 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["S. Kayser, J. Krzykalla, M.A. Elliott, K. Norsworthy, P. Gonzales, R.K. Hills, M.R. Baer, Z. Ráčil, J. Mayer, J. Novak, P. Žák, T. Szotkowski, D. Grimwade, N.H. Russell, R.B. Walter, E H. Estey, J. Westermann, M. Görner, A. Benner, A. Krämer, B.D. Smith, A.K. Burnett, C. Thiede, C. Röllig, A.D. Ho, G. Ehninger, R.F. Schlenk, M.S. Tallman, M.J. Levis and U. Platzbecker"]},"language":["eng"],"title":[{"title":"Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide","title_sort":"Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide"}],"relHost":[{"title":[{"title_sort":"Leukemia","title":"Leukemia","subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal"}],"language":["eng"],"disp":"Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxideLeukemia","id":{"zdb":["2008023-2"],"eki":["32046699X"],"issn":["1476-5551"]},"recId":"32046699X","note":["Gesehen am 15.03.04"],"origin":[{"dateIssuedKey":"1997","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","dateIssuedDisp":"1997-","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"2347-2354","volume":"31","extent":"8","issue":"11","year":"2017","text":"31(2017), 11, Seite 2347-2354"},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Nachgewiesen 11.1997 -"]}],"recId":"1578060389","person":[{"display":"Kayser, Sabine","family":"Kayser","role":"aut","roleDisplay":"VerfasserIn","given":"Sabine"},{"given":"Axel","role":"aut","roleDisplay":"VerfasserIn","display":"Benner, Axel","family":"Benner"},{"given":"Alwin","display":"Krämer, Alwin","family":"Krämer","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Anthony Dick","roleDisplay":"VerfasserIn","role":"aut","family":"Ho","display":"Ho, Anthony Dick"},{"family":"Schlenk","display":"Schlenk, Richard Friedrich","roleDisplay":"VerfasserIn","role":"aut","given":"Richard Friedrich"}],"id":{"doi":["10.1038/leu.2017.92"],"eki":["1578060389"]},"note":["Gesehen am 30.07.2018"]} | ||
| SRT | |a KAYSERSABICHARACTERI1820 | ||