Predictive risk factors for patients with cirrhosis undergoing heart surgery
BACKGROUND: Empiric experiences suggest higher mortality and complication risk for patients with cirrhosis of the liver after cardiac surgery. However, cirrhosis is not considered a risk factor in either the EuroSCORE or The Society of Thoracic Surgeons score. We report a large single-center experie...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 August 2012
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| In: |
The annals of thoracic surgery
Year: 2012, Jahrgang: 94, Heft: 6, Pages: 1947-1952 |
| ISSN: | 1552-6259 |
| DOI: | 10.1016/j.athoracsur.2012.06.057 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.athoracsur.2012.06.057
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| Verfasserangaben: | Rawa Arif, Philipp Seppelt, Simon Schwill, Dubravka Kojic, Ali Ghodsizad, Arjang Ruhparwar, Matthias Karck, and Klaus Kallenbach |
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| 245 | 1 | 0 | |a Predictive risk factors for patients with cirrhosis undergoing heart surgery |c Rawa Arif, Philipp Seppelt, Simon Schwill, Dubravka Kojic, Ali Ghodsizad, Arjang Ruhparwar, Matthias Karck, and Klaus Kallenbach |
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| 520 | |a BACKGROUND: Empiric experiences suggest higher mortality and complication risk for patients with cirrhosis of the liver after cardiac surgery. However, cirrhosis is not considered a risk factor in either the EuroSCORE or The Society of Thoracic Surgeons score. We report a large single-center experience of patients with cirrhosis undergoing cardiac surgery with extracorporeal circulation and aimed to evaluate the severity of cirrhosis as a predictor of outcome. METHODS: During 2001 and 2011, we operated on 109 consecutive patients (average age, 64 years; 82 male) diagnosed for cirrhosis with cardiopulmonary bypass for different indications. Thirty-day mortality and long-term mortality were set as primary study end points. RESULTS: Thirty-day mortality was 26%, and 5-year survival was 19%. Patients categorized as Child-Turcotte-Pugh (CHILD) C (n=6; 67% 30-day survival; 0% 5-year survival) and B (n=30; 60%; 5%) had worse 30-day and 5-year survival compared with patients categorized as CHILD A (n=73; 80%; 25%). For 30-day mortality, preoperative EuroSCORE (p=0.015), model for end-stage liver disease (MELD) score (p=0.006), albumin (p=0.023), total protein (p=0.01), and myocardial infarction (p=0.049) revealed significant differences between survivors and nonsurvivors. Multivariate logistic regression identified only MELD score (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.03 to 1.23; p=0.011) and total protein (OR, 0.97; 95% CI, 0.95 to 1; p=0.049) were connected with increased 30-day mortality. Cox regression analysis revealed EuroSCORE (OR, 1.02; 95% CI, 1.01 to 1.03; p<0.0001) and MELD (OR, 1.06; 95% CI, 1.01 to 1.12; p=0.016) predicting the overall mortality. Receiver operating characteristic analysis indicated significant predictive power of MELD (p=0.001) and EuroSCORE (p=0.027) for 30-day mortality. CONCLUSIONS: Patients with cirrhosis undergoing heart surgery with extracorporeal circulation have a poor prognosis. Several preoperative factors are related to outcome. EuroSCORE and MELD score may help to evaluate operation risk and indication. | ||
| 650 | 4 | |a Biopsy | |
| 650 | 4 | |a Cardiac Surgical Procedures | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Germany | |
| 650 | 4 | |a Heart Diseases | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Liver Cirrhosis | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Retrospective Studies | |
| 650 | 4 | |a Risk Assessment | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Survival Rate | |
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