Effect of local zoledronate on implant osseointegration in a rat model
An implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated Zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim of this study was to investigate the release kinetics of the chosen coating and the effe...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 March 2012
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| In: |
BMC musculoskeletal disorders
Year: 2012, Jahrgang: 13, Heft: 1, Pages: 42-50 |
| ISSN: | 1471-2474 |
| DOI: | 10.1186/1471-2474-13-42 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2474-13-42 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2474-13-42 
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| Verfasserangaben: | David A. Back, Stephan Pauly, Lisa Rommel, Norbert P. Haas, Gerhard Schmidmaier, Britt Wildemann and Stefan H. Greiner |
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| 520 | |a An implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated Zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim of this study was to investigate the release kinetics of the chosen coating and the effect of different concentrations of ZOL locally released from this coating on the osseointegration of implants. | ||
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