Murine models of diabetic nephropathy

Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features o...

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Hauptverfasser: Peters, Verena (VerfasserIn) , Schmitt, Claus P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 08. März 2012
In: Experimental and clinical endocrinology & diabetes
Year: 2012, Jahrgang: 120, Heft: 4, Pages: 191-193
ISSN:1439-3646
DOI:10.1055/s-0032-1304569
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1055/s-0032-1304569
Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1304569
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Verfasserangaben:V. Peters, C.P. Schmitt

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520 |a Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features of diabetic nephropathy. The critical analysis and comparison of existing mouse models substantially enhances our understanding of the disease process and should provide a guide for choosing the most suitable mouse model for the investigation of diabetic nephropathy. 
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