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CD4+CD25+Foxp3+IFNγ+ Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC

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IFNγ-producing CD3+CD4+CD25+Foxp3+ induced Treg are more frequently detectable in patients with good than in patients with impaired long-term kidney graft function. We investigated the in-vitro function of separated CD3+CD4+CD25+Foxp3+IFNγ+ PBL that were induced by phorbol-12-myristate-13-acetate(PM...

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Bibliographic Details
Main Authors: Daniel, Volker (Author) , Sadeghi, Mahmoud (Author) , Wang, Haihao (Author) , Opelz, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 20 August 2012
In: Transplant immunology
Year: 2012, Volume: 27, Issue: 2-3, Pages: 114-121
ISSN:1878-5492
DOI:10.1016/j.trim.2012.08.003
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.trim.2012.08.003
Verlag, Volltext: http://linkinghub.elsevier.com/retrieve/pii/S0966327412000883
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Author Notes:Volker Daniel, Mahmoud Sadeghi, Haihao Wang, Gerhard Opelz
Description
Summary:IFNγ-producing CD3+CD4+CD25+Foxp3+ induced Treg are more frequently detectable in patients with good than in patients with impaired long-term kidney graft function. We investigated the in-vitro function of separated CD3+CD4+CD25+Foxp3+IFNγ+ PBL that were induced by phorbol-12-myristate-13-acetate(PMA)/Ionomycin or alloantigenic stimulation. Additionally, we studied iTreg induction and cell proliferation in MLC with pretransplant obtained PBL.
Item Description:Gesehen am 02.08.2018
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Physical Description:Online Resource
ISSN:1878-5492
DOI:10.1016/j.trim.2012.08.003

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