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Climacteric lowers plasma levels of platelet-derived microparticles: a pilot study in pre-versus postmenopausal women

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Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet- (PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma levels of microparticles (MP) were compared...

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Hauptverfasser: Rank, Andreas (VerfasserIn) , Rösner, Sabine (VerfasserIn) , Toth, Bettina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 23, 2012
In: Acta haematologica
Year: 2012, Jahrgang: 128, Heft: 1, Pages: 53-59
ISSN:1421-9662
DOI:10.1159/000337327
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1159/000337327
Verlag, Volltext: https://www.karger.com/Article/FullText/337327
Volltext
Verfasserangaben:Andreas Rank, Rienk Nieuwland, Sabine Roesner, Katharina Nikolajek, Erhard Hiller, Bettina Toth

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520 |a Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet- (PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma levels of microparticles (MP) were compared in 21 premenopausal and 19 postmenopausal women. Results: No altered numbers of total MP or EMP were measured within the study groups. However, the plasma values of CD61-exposing MP from platelets/megakaryocytes were higher in premenopausal women. This differentiation was also significant for the subgroup of premenopausal women without hormonal contraceptives. Furthermore, in premenopausal women, higher plasma levels of PMP exposing CD62P were also present as compared to postmenopausal women. This difference was also true for CD63+ PMP levels. Conclusion: Climacteric lowers the level of PMP but has no impact on the number of EMP in women. These data suggest that PMP and EMP do not play a significant role in enhancing the risk of thrombotic events in healthy, postmenopausal women. 
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