Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A
The randomized phase III trial TARGIT A showed non-inferiority regarding local control after intraoperative radiotherapy (IORT 20 Gy which was followed by whole breast radiotherapy (WBRT) in patients with risk factors only) in comparison to standard WBRT (50-56 Gy) after breast-conserving surgery in...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 July 2012
|
| In: |
Breast cancer research and treatment
Year: 2012, Jahrgang: 135, Heft: 1, Pages: 253-260 |
| ISSN: | 1573-7217 |
| DOI: | 10.1007/s10549-012-2168-4 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s10549-012-2168-4 Verlag, Volltext: https://link.springer.com/article/10.1007/s10549-012-2168-4 
|
| Verfasserangaben: | Elena Sperk, Grit Welzel, Anke Keller, Uta Kraus-Tiefenbacher, Axel Gerhardt, Marc Sütterlin, Frederik Wenz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1578242339 | ||
| 003 | DE-627 | ||
| 005 | 20220814205521.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180803s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10549-012-2168-4 |2 doi | |
| 035 | |a (DE-627)1578242339 | ||
| 035 | |a (DE-576)508242339 | ||
| 035 | |a (DE-599)BSZ508242339 | ||
| 035 | |a (OCoLC)1341016091 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sperk, Elena |d 1983- |e VerfasserIn |0 (DE-588)141654252 |0 (DE-627)630406650 |0 (DE-576)325031231 |4 aut | |
| 245 | 1 | 0 | |a Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer |b results from the randomized phase III trial TARGIT A |c Elena Sperk, Grit Welzel, Anke Keller, Uta Kraus-Tiefenbacher, Axel Gerhardt, Marc Sütterlin, Frederik Wenz |
| 264 | 1 | |c 29 July 2012 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.08.2018 | ||
| 520 | |a The randomized phase III trial TARGIT A showed non-inferiority regarding local control after intraoperative radiotherapy (IORT 20 Gy which was followed by whole breast radiotherapy (WBRT) in patients with risk factors only) in comparison to standard WBRT (50-56 Gy) after breast-conserving surgery in selected patients. This is the first analysis of long-term toxicities in the setting of TARGIT. Between 02/2002 and 12/2008, 305 patients were treated within TARGIT A (Arm A: n = 34 IORT, n = 20 IORT + WBRT for risk factors; Arm B WBRT: n = 55) or received IORT as a planned boost (control group: n = 196) at a single center. Toxicity was assessed according to the LENT SOMA scales. No significant differences were seen between Arm A and Arm B regarding fibrosis, breast edema, retraction, ulceration, lymphedema, hyperpigmentation, and pain. Arm A had significantly less telangiectases compared to Arm B (p = 0.049). In the subanalysis (Arm A IORT vs. Arm A IORT + WBRT vs. Arm B), fibrosis had a cumulative rate of 5.9 versus 37.5 versus 18.4 %, respectively (38.2 % IORT boost control group), at 3 years. No telangiectases were seen after IORT alone (0 % Arm A IORT vs. 17.5 % Arm A IORT + WBRT vs. 17.7 % Arm B). The hazard ratio of higher grade toxicity as first event was 0.46 (95 % CI, 0.26-0.83) for Arm A IORT as compared to Arm B (p = 0.010). No recurrences were seen after a median follow-up of 40 months (Arm A) and 42 months (Arm B). With its very low chronic skin toxicity rates and outstanding long-term results regarding toxicity and local control, IORT with 50 kV X-rays is a safe and effective method for treatment of selected breast cancer patients. | ||
| 700 | 1 | |a Welzel, Grit |d 1969- |e VerfasserIn |0 (DE-588)1034853139 |0 (DE-627)74633754X |0 (DE-576)382474031 |4 aut | |
| 700 | 1 | |a Keller, Anke |d 1976- |e VerfasserIn |0 (DE-588)1069407062 |0 (DE-627)821870610 |0 (DE-576)428682081 |4 aut | |
| 700 | 1 | |a Kraus-Tiefenbacher, Uta |d 1969- |e VerfasserIn |0 (DE-588)1013173406 |0 (DE-627)704975718 |0 (DE-576)346656990 |4 aut | |
| 700 | 1 | |a Gerhardt, Axel |d 1976- |e VerfasserIn |0 (DE-588)133080536 |0 (DE-627)534474993 |0 (DE-576)266256503 |4 aut | |
| 700 | 1 | |a Sütterlin, Marc |d 1967- |e VerfasserIn |0 (DE-588)102644067X |0 (DE-627)72673389X |0 (DE-576)371782651 |4 aut | |
| 700 | 1 | |a Wenz, Frederik |d 1966- |e VerfasserIn |0 (DE-588)113310390 |0 (DE-627)663837766 |0 (DE-576)346656281 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Breast cancer research and treatment |d Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 |g 135(2012), 1, Seite 253-260 |h Online-Ressource |w (DE-627)320433722 |w (DE-600)2004077-5 |w (DE-576)104194162 |x 1573-7217 |7 nnas |a Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer results from the randomized phase III trial TARGIT A |
| 773 | 1 | 8 | |g volume:135 |g year:2012 |g number:1 |g pages:253-260 |g extent:8 |a Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer results from the randomized phase III trial TARGIT A |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10549-012-2168-4 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s10549-012-2168-4 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180803 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 113310390 |a Wenz, Frederik |m 113310390:Wenz, Frederik |d 60000 |d 63000 |e 60000PW113310390 |e 63000PW113310390 |k 0/60000/ |k 1/60000/63000/ |p 7 |y j | ||
| 998 | |g 102644067X |a Sütterlin, Marc |m 102644067X:Sütterlin, Marc |d 60000 |d 61300 |e 60000PS102644067X |e 61300PS102644067X |k 0/60000/ |k 1/60000/61300/ |p 6 | ||
| 998 | |g 133080536 |a Gerhardt, Axel |m 133080536:Gerhardt, Axel |d 60000 |d 61300 |e 60000PG133080536 |e 61300PG133080536 |k 0/60000/ |k 1/60000/61300/ |p 5 | ||
| 998 | |g 1013173406 |a Kraus-Tiefenbacher, Uta |m 1013173406:Kraus-Tiefenbacher, Uta |d 60000 |d 63000 |e 60000PK1013173406 |e 63000PK1013173406 |k 0/60000/ |k 1/60000/63000/ |p 4 | ||
| 998 | |g 1069407062 |a Keller, Anke |m 1069407062:Keller, Anke |d 60000 |d 63000 |e 60000PK1069407062 |e 63000PK1069407062 |k 0/60000/ |k 1/60000/63000/ |p 3 | ||
| 998 | |g 1034853139 |a Welzel, Grit |m 1034853139:Welzel, Grit |d 60000 |d 63000 |e 60000PW1034853139 |e 63000PW1034853139 |k 0/60000/ |k 1/60000/63000/ |p 2 | ||
| 998 | |g 141654252 |a Sperk, Elena |m 141654252:Sperk, Elena |d 60000 |d 63000 |e 60000PS141654252 |e 63000PS141654252 |k 0/60000/ |k 1/60000/63000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1578242339 |e 3020192277 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 03.08.2018"],"physDesc":[{"extent":"8 S."}],"id":{"eki":["1578242339"],"doi":["10.1007/s10549-012-2168-4"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1573-7217"],"zdb":["2004077-5"],"eki":["320433722"]},"note":["Gesehen am 02.12.05","Fortsetzung der Druck-Ausgabe"],"part":{"issue":"1","pages":"253-260","year":"2012","volume":"135","extent":"8","text":"135(2012), 1, Seite 253-260"},"pubHistory":["1.1981 -"],"title":[{"title_sort":"Breast cancer research and treatment","title":"Breast cancer research and treatment"}],"recId":"320433722","disp":"Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer results from the randomized phase III trial TARGIT ABreast cancer research and treatment","origin":[{"dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","publisher":"Springer Science + Business Media B.V. ; Kluwer"}],"language":["eng"]}],"origin":[{"dateIssuedDisp":"29 July 2012","dateIssuedKey":"2012"}],"recId":"1578242339","language":["eng"],"person":[{"roleDisplay":"VerfasserIn","family":"Sperk","display":"Sperk, Elena","role":"aut","given":"Elena"},{"roleDisplay":"VerfasserIn","given":"Grit","role":"aut","display":"Welzel, Grit","family":"Welzel"},{"given":"Anke","role":"aut","family":"Keller","display":"Keller, Anke","roleDisplay":"VerfasserIn"},{"display":"Kraus-Tiefenbacher, Uta","family":"Kraus-Tiefenbacher","given":"Uta","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Gerhardt","display":"Gerhardt, Axel","given":"Axel","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Sütterlin","display":"Sütterlin, Marc","given":"Marc","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Frederik","family":"Wenz","display":"Wenz, Frederik"}],"title":[{"title":"Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer","subtitle":"results from the randomized phase III trial TARGIT A","title_sort":"Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer"}],"name":{"displayForm":["Elena Sperk, Grit Welzel, Anke Keller, Uta Kraus-Tiefenbacher, Axel Gerhardt, Marc Sütterlin, Frederik Wenz"]}} | ||
| SRT | |a SPERKELENALATERADIAT2920 | ||