Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis
Kaemmerer E, Schneider U, Klaus C, Plum P, Reinartz A, Adolf M, Renner M, Wolfs T G A M, Kramer B W, Wagner N, Mollenhauer J & Gassler N (2012) Histopathology 60, 561-569 Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis Aims: Deleted in mal...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 February 2012
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| In: |
Histopathology
Year: 2012, Volume: 60, Issue: 4, Pages: 561-569 |
| ISSN: | 1365-2559 |
| DOI: | 10.1111/j.1365-2559.2011.04159.x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/j.1365-2559.2011.04159.x Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2559.2011.04159.x 
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| Author Notes: | Elke Kaemmerer, Ursula Schneider, Christina Klaus, Patrick Plum, Andrea Reinartz, Maximilian Adolf, Marcus Renner, Tim G.A.M. Wolfs, Boris W. Kramer, Norbert Wagner, Jan Mollenhauer, Nikolaus Gassler |
| Summary: | Kaemmerer E, Schneider U, Klaus C, Plum P, Reinartz A, Adolf M, Renner M, Wolfs T G A M, Kramer B W, Wagner N, Mollenhauer J & Gassler N (2012) Histopathology 60, 561-569 Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis Aims: Deleted in malignant brain tumours 1 (DMBT1; gp340) is a secreted glycoprotein which is found in the surface lining epithelia of human small and large intestine. DMBT1 is suggested to play a role in enterocyte differentiation and surface protection from intestinal bacteria. The aim of this study was to elucidate DMBT1 expression in bacteria-related active intestinal inflammation such as appendicitis. Methods and results: mRNA and protein levels of DMBT1 were analysed in surgical resections of 50 appendices (active inflammation: n = 25). In non-actively inflamed appendices, inter-individual differences in basal DMBT1 levels of enterocytes and some non-epithelial cells were found. In active appendicitis, enterocytic DMBT1 mRNA expression was increased approximately fivefold, which was paralleled by a corresponding increase of cytoplasmic and secreted DMBT1 protein levels. Increased DMBT1 expression was predominant in enterocytes adjacent to erosive lesions or ulcers. Conclusions: Our data demonstrate that bacteria-related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. These findings substantiate the view that DMBT1 is of functional relevance for host defence and modulation of the course of intestinal bacteria-related inflammatory responses. |
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| Item Description: | Gesehen am 07.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1365-2559 |
| DOI: | 10.1111/j.1365-2559.2011.04159.x |