Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10−9) and 7p15.3 (rs448764...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
Nature genetics
Year: 2011, Jahrgang: 44, Heft: 1, Pages: 58-61 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng.993 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/ng.993 Verlag, Volltext: https://www.nature.com/articles/ng.993 
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| Verfasserangaben: | Peter Broderick, Daniel Chubb, David C. Johnson, Niels Weinhold, Asta Försti, Amy Lloyd, Bianca Olver, Yussanne P. Ma, Sara E. Dobbins, Brian A. Walker, Faith E. Davies, Walter A. Gregory, J. Anthony Child, Fiona M. Ross, Graham H. Jackson, Kai Neben, Anna Jauch, Per Hoffmann, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Ian P. Tomlinson, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan & Richard S. Houlston |
| Zusammenfassung: | To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10−9) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10−15). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10−7). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights. |
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| Beschreibung: | Published: 27 November 2011 Gesehen am 07.08.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng.993 |