Buchumschlag

A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study

Background: Adequate anticoagulation is prerequisite for effective hemodialysis to prevent clotting in the extracorporeal circuit. We aimed providing first data on the efficacy and safety of the low-molecular-weight heparin certoparin in this setting. Methods: Multicenter, open-label, 8-week trial....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Dorsch, Oliver Kurt (VerfasserIn) , Harenberg, Job (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 June 2012
In: BMC nephrology
Year: 2012, Jahrgang: 13, Pages: 1-10
ISSN:1471-2369
DOI:10.1186/1471-2369-13-50
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2369-13-50
Verlag, $4LFVolltext: http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-13-50
Volltext
Verfasserangaben:Oliver Dorsch, Detlef H Krieter, Horst-Dieter Lemke, Stefan Fischer, Nima Melzer, Christian Sieder, Peter Bramlage and Job Harenberg

MARC

LEADER 00000caa a2200000 c 4500
001 1578358698
003 DE-627
005 20230426230901.0
007 cr uuu---uuuuu
008 180808s2012 xx |||||o 00| ||eng c
024 7 |a 10.1186/1471-2369-13-50  |2 doi 
035 |a (DE-627)1578358698 
035 |a (DE-576)508358698 
035 |a (DE-599)BSZ508358698 
035 |a (OCoLC)1341016161 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Dorsch, Oliver Kurt  |d 1970-  |e VerfasserIn  |0 (DE-588)120515466  |0 (DE-627)696743574  |0 (DE-576)292258682  |4 aut 
245 1 2 |a A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study  |c Oliver Dorsch, Detlef H Krieter, Horst-Dieter Lemke, Stefan Fischer, Nima Melzer, Christian Sieder, Peter Bramlage and Job Harenberg 
264 1 |c 28 June 2012 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.08.2018 
520 |a Background: Adequate anticoagulation is prerequisite for effective hemodialysis to prevent clotting in the extracorporeal circuit. We aimed providing first data on the efficacy and safety of the low-molecular-weight heparin certoparin in this setting. Methods: Multicenter, open-label, 8-week trial. Patients received a single dose of 3,000 IU certoparin i.v. with additional titration steps of 600 IU and/or continuous infusion if necessary. Results: 120 patients were screened, 109 enrolled (median age 71; range 26-90 years) and 106 available for efficacy analyses. The percentage of unsatisfactory dialysis results at 8 weeks due to clotting or bleeding, was 1.9% (n = 2/106; 95% confidence interval [CI] 0.23-6.65%); no major bleeding. 1.9% had moderate/severe clotting in the lines/bubble catcher and 2.8% in the dialyser at week 8. 15.7 ± 14.3% of the dialysis filters’ visual surface area was showing redness. In subgroups of patients receiving median doses of 3000 ± 0, 3000 (2400-6000) and 4200 (3000-6600) IU, plasma aXa levels at baseline, 4 and 8 weeks were 0.24 [95%CI 0.21-0.27], 0.33 [0.27-0.40] and 0.38 [0.33-0.45] aXa IU/ml at 2 h. C48h was 0.01 [0.01-0.02] aXa IU at all visits. At baseline and 4 weeks AUC0-48h was 2.66 [2.19-3.24] and 3.66 [3.00-4.45] aXa IU*h/ml. In 3.0% of dialyses (n = 83/2724) prolonged fistula compression times were documented. Eight patients (7.34%) had at least one episode of minor bleeding. 4) 85.3% of patients had any adverse event, 9.2% were serious without suspected drug relation; and in 32 patients a drug-relation was suspected. Conclusions: Certoparin appears effective and safe for anticoagulation in patients undergoing maintenance hemodialysis. 
700 1 |a Harenberg, Job  |d 1950-  |e VerfasserIn  |0 (DE-588)108825507  |0 (DE-627)655891498  |0 (DE-576)339563745  |4 aut 
773 0 8 |i Enthalten in  |t BMC nephrology  |d London : BioMed Central, 2000  |g 13(2012), Artikel-ID 50, Seite 1-10  |h Online-Ressource  |w (DE-627)326643672  |w (DE-600)2041348-8  |w (DE-576)107014629  |x 1471-2369  |7 nnas  |a A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study 
773 1 8 |g volume:13  |g year:2012  |g elocationid:50  |g pages:1-10  |g extent:10  |a A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study 
856 4 0 |u http://dx.doi.org/10.1186/1471-2369-13-50  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-13-50  |x Verlag  |3 $4LFVolltext 
951 |a AR 
992 |a 20180808 
993 |a Article 
994 |a 2012 
998 |g 108825507  |a Harenberg, Job  |m 108825507:Harenberg, Job  |d 60000  |d 65400  |e 60000PH108825507  |e 65400PH108825507  |k 0/60000/  |k 1/60000/65400/  |p 8  |y j 
999 |a KXP-PPN1578358698  |e 3020401925 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"doi":["10.1186/1471-2369-13-50"],"eki":["1578358698"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"28 June 2012"}],"name":{"displayForm":["Oliver Dorsch, Detlef H Krieter, Horst-Dieter Lemke, Stefan Fischer, Nima Melzer, Christian Sieder, Peter Bramlage and Job Harenberg"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2000","publisher":"BioMed Central","dateIssuedDisp":"2000-","publisherPlace":"London"}],"id":{"issn":["1471-2369"],"zdb":["2041348-8"],"eki":["326643672"]},"note":["Gesehen am 20. Januar 2016"],"disp":"A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane studyBMC nephrology","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"326643672","language":["eng"],"pubHistory":["1.2000 -"],"part":{"text":"13(2012), Artikel-ID 50, Seite 1-10","volume":"13","extent":"10","year":"2012","pages":"1-10"},"title":[{"title_sort":"BMC nephrology","title":"BMC nephrology"}]}],"physDesc":[{"extent":"10 S."}],"title":[{"title":"A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study","title_sort":"multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis - the membrane study"}],"person":[{"role":"aut","display":"Dorsch, Oliver Kurt","roleDisplay":"VerfasserIn","given":"Oliver Kurt","family":"Dorsch"},{"roleDisplay":"VerfasserIn","display":"Harenberg, Job","role":"aut","family":"Harenberg","given":"Job"}],"language":["eng"],"recId":"1578358698","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.08.2018"]} 
SRT |a DORSCHOLIVMULTICENTE2820 

Ähnliche Einträge