Modeling regulation of zinc uptake via ZIP transporters in east and plant roots
In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into t...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 8, 2012
|
| In: |
PLOS ONE
Year: 2012, Jahrgang: 7, Heft: 6, Pages: 1-11 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0037193 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0037193 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037193 
|
| Verfasserangaben: | Juliane Claus, Andrés Chavarría-Krauser |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1578363810 | ||
| 003 | DE-627 | ||
| 005 | 20230503124439.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180808s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0037193 |2 doi | |
| 035 | |a (DE-627)1578363810 | ||
| 035 | |a (DE-576)508363810 | ||
| 035 | |a (DE-599)BSZ508363810 | ||
| 035 | |a (OCoLC)1341016333 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Claus, Juliane |e VerfasserIn |0 (DE-588)1036653102 |0 (DE-627)750687576 |0 (DE-576)384989578 |4 aut | |
| 245 | 1 | 0 | |a Modeling regulation of zinc uptake via ZIP transporters in east and plant roots |c Juliane Claus, Andrés Chavarría-Krauser |
| 264 | 1 | |c June 8, 2012 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.08.2018 | ||
| 520 | |a In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into the underlying mechanisms, starting from a general model based on ordinary differential equations and adapting it to the specific cases of yeast and plant root cells. In yeast, zinc is transported by the transporters ZRT1 and ZRT2, which are both regulated by the zinc-responsive transcription factor ZAP1. Using biological data, parameters were estimated and analyzed, confirming the different affinities of ZRT1 and ZRT2 reported in the literature. Furthermore, our model suggests that the positive feedback in ZAP1 production has a stabilizing function at high influx rates. In plant roots, various ZIP transporters play a role in zinc uptake. Their regulation is largely unknown, but bZIP transcription factors are thought to be involved. We set up three putative models based on: an activator only, an activator with dimerization and an activator-inhibitor pair. These were fitted to measurements and analyzed. Simulations show that the activator-inhibitor model outperforms the other two in providing robust and stable homeostasis at reasonable parameter ranges. | ||
| 650 | 4 | |a Dimerization | |
| 650 | 4 | |a Homeostasis | |
| 650 | 4 | |a Micronutrient deficiencies | |
| 650 | 4 | |a Plant roots | |
| 650 | 4 | |a Transcription factors | |
| 650 | 4 | |a Transcriptional control | |
| 650 | 4 | |a Yeast and fungal models | |
| 650 | 4 | |a Zinc | |
| 700 | 1 | |a Chavarría-Krauser, Andrés |e VerfasserIn |0 (DE-588)132929325 |0 (DE-627)528684280 |0 (DE-576)299509672 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 7(2012), 6, Artikel-ID 37193, Seite 1-11 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Modeling regulation of zinc uptake via ZIP transporters in east and plant roots |
| 773 | 1 | 8 | |g volume:7 |g year:2012 |g number:6 |g elocationid:37193 |g pages:1-11 |g extent:11 |a Modeling regulation of zinc uptake via ZIP transporters in east and plant roots |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0037193 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037193 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180808 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 132929325 |a Chavarría-Krauser, Andrés |m 132929325:Chavarría-Krauser, Andrés |d 700000 |d 716000 |e 700000PC132929325 |e 716000PC132929325 |k 0/700000/ |k 1/700000/716000/ |p 2 |y j | ||
| 998 | |g 1036653102 |a Claus, Juliane |m 1036653102:Claus, Juliane |p 1 |x j | ||
| 999 | |a KXP-PPN1578363810 |e 3020408547 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Juliane","family":"Claus","role":"aut","roleDisplay":"VerfasserIn","display":"Claus, Juliane"},{"given":"Andrés","family":"Chavarría-Krauser","role":"aut","display":"Chavarría-Krauser, Andrés","roleDisplay":"VerfasserIn"}],"title":[{"title":"Modeling regulation of zinc uptake via ZIP transporters in east and plant roots","title_sort":"Modeling regulation of zinc uptake via ZIP transporters in east and plant roots"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.08.2018"],"recId":"1578363810","language":["eng"],"name":{"displayForm":["Juliane Claus, Andrés Chavarría-Krauser"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"June 8, 2012"}],"id":{"doi":["10.1371/journal.pone.0037193"],"eki":["1578363810"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Public Library of Science"]},"origin":[{"dateIssuedKey":"2006","publisher":"PLOS ; PLoS","dateIssuedDisp":"2006-","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"id":{"issn":["1932-6203"],"zdb":["2267670-3"],"eki":["523574592"]},"disp":"Modeling regulation of zinc uptake via ZIP transporters in east and plant rootsPLOS ONE","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"recId":"523574592","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Public Library of Science","role":"isb"}],"language":["eng"],"pubHistory":["1.2006 -"],"part":{"extent":"11","text":"7(2012), 6, Artikel-ID 37193, Seite 1-11","volume":"7","pages":"1-11","issue":"6","year":"2012"},"title":[{"title_sort":"PLOS ONE","title":"PLOS ONE"}]}]} | ||
| SRT | |a CLAUSJULIAMODELINGRE8201 | ||