In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function

Background: IFNγ-producing CD4+CD25+Foxp3+ PBL represent a subtype of iTreg that are associated with good long-term graft outcome in renal transplant recipients and suppress alloresponses in-vitro. To study the mechanism of immunosuppression, we attempted to block cell surface receptors and thereby...

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Hauptverfasser:	Daniel, Volker (VerfasserIn) , Sadeghi, Mahmoud (VerfasserIn) , Wang, Haihao (VerfasserIn) , Opelz, Gerhard (VerfasserIn)
Dokumenttyp:	Article (Journal)
Sprache:	Englisch
Veröffentlicht:	21 August 2012
In:	BMC immunology Year: 2012, Jahrgang: 13, Heft: 1
ISSN:	1471-2172
DOI:	10.1186/1471-2172-13-47
Online-Zugang:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2172-13-47 Verlag, Volltext: http://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-13-47
Verfasserangaben:	Volker Daniel, Mahmoud Sadeghi, Haihao Wang and Gerhard Opelz

CD4+CD25+Foxp3+IFNγ+ Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC von Daniel, Volker (VerfasserIn) , Sadeghi, Mahmoud (VerfasserIn) , Wang, Haihao (VerfasserIn) , Opelz, Gerhard (VerfasserIn) ,

in: Transplant immunology, 27 (2012), 2-3, Seite 114-121

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In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function

CD4+CD25+Foxp3+IFNγ+ Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC von Daniel, Volker (VerfasserIn) , Sadeghi, Mahmoud (VerfasserIn) , Wang, Haihao (VerfasserIn) , Opelz, Gerhard (VerfasserIn) ,

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