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RIP3 attenuates the pancreatic damage induced by deletion of ATG7

Invalidation of pancreatic autophagy entails pancreatic atrophy, endocrine and exocrine insufficiency and pancreatitis. The aim of this study was to investigate whether depletion of Rip3, which is involved in necroptotic signaling, may attenuate the pancreatic atrophy and pancreatitis resulting from...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Xiaodong (VerfasserIn) , Xie, Li (VerfasserIn) , Xia, Leizhou (VerfasserIn) , Bergmann, Frank (VerfasserIn) , Büchler, Markus W. (VerfasserIn) , Hackert, Thilo (VerfasserIn) , Fortunato, Franco (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 July 2017
In: Cell death & disease
Year: 2017, Jahrgang: 8, Heft: 7, Pages: e2918
ISSN:2041-4889
DOI:10.1038/cddis.2017.313
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/cddis.2017.313
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/cddis2017313
Volltext
Verfasserangaben:Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W. Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato
Beschreibung
Zusammenfassung:Invalidation of pancreatic autophagy entails pancreatic atrophy, endocrine and exocrine insufficiency and pancreatitis. The aim of this study was to investigate whether depletion of Rip3, which is involved in necroptotic signaling, may attenuate the pancreatic atrophy and pancreatitis resulting from autophagy inhibition. Autophagy and necroptosis signaling were evaluated in mice lacking expression of Rip3 in all organs and Atg7 in the pancreas. Acinar cell death, inflammation and fibrosis were evaluated by using of a compendium of immunofluorescence methods and immunoblots. Mice deficient for pancreatic Atg7 developed acute pancreatitis, which progressed to chronic pancreatitis. This phenotype reduces autophagy, increase apoptosis and necroptosis, inflammation and fibrosis, as well as premature death of the animals. Knockout of Rip3 exacerbated the apoptotic death of acinar cells, increased tissue damage, reduced macrophage infiltration and further accelerated the death of the mice with Atg7-deficient pancreas. The pancreatic degeneration induced by autophagy inhibition was exacerbated by Rip3 deletion.
Beschreibung:Gesehen am 10.07.2020
Beschreibung:Online Resource
ISSN:2041-4889
DOI:10.1038/cddis.2017.313

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