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A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma

Local control rates in patients with retroperitoneal soft tissue sarcoma (RSTS) remain disappointing even after gross total resection, mainly because wide margins are not achievable in the majority of patients. In contrast to extremity sarcoma, postoperative radiation therapy (RT) has shown limited...

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Main Authors: Röder, Falk (Author) , Huber, Peter E. (Author) , Edler, Lutz (Author) , Habl, Gregor (Author) , Oertel, Susanne (Author) , Saleh-Ebrahimi, Ladan (Author) , Hensley, Frank W. (Author) , Büchler, Markus W. (Author) , Debus, Jürgen (Author) , Koch, Moritz (Author) , Weitz, Jürgen (Author) , Bischof, Marc (Author)
Format: Article (Journal)
Language:English
Published: 12 July 2012
In: BMC cancer
Year: 2012, Volume: 12
ISSN:1471-2407
DOI:10.1186/1471-2407-12-287
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2407-12-287
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2407-12-287
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Author Notes:Falk Roeder, Daniela Schulz-Ertner, Anna V. Nikoghosyan, Peter E. Huber, Lutz Edler, Gregor Habl, Robert Krempien, Susanne Oertel, Ladan Saleh-Ebrahimi, Frank W. Hensley, Markus W. Buechler, Juergen Debus, Moritz Koch, Juergen Weitz and Marc Bischof
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Summary:Local control rates in patients with retroperitoneal soft tissue sarcoma (RSTS) remain disappointing even after gross total resection, mainly because wide margins are not achievable in the majority of patients. In contrast to extremity sarcoma, postoperative radiation therapy (RT) has shown limited efficacy due to its limitations in achievable dose and coverage. Although Intraoperative Radiation Therapy (IORT) has been introduced in some centers to overcome the dose limitations and resulted in increased outcome, local failure rates are still high even if considerable treatment related toxicity is accepted. As postoperative administration of RT has some general disadvantages, neoadjuvant approaches could offer benefits in terms of dose escalation, target coverage and reduction of toxicity, especially if highly conformal techniques like intensity-modulated radiation therapy (IMRT) are considered.
Item Description:Gesehen am 14.08.2018
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-12-287

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