Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands
Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have sugges...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 July 2012
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| In: |
Fluids and barriers of the CNS
Year: 2012, Volume: 9, Issue: 1 |
| ISSN: | 2045-8118 |
| DOI: | 10.1186/2045-8118-9-14 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/2045-8118-9-14 Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/2045-8118-9-14 
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| Author Notes: | Sven Jarius, Peter Eichhorn, Brigitte Wildemann and Manfred Wick |
| Summary: | Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis. |
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| Item Description: | Gesehen am 15.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2045-8118 |
| DOI: | 10.1186/2045-8118-9-14 |