Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial
BACKGROUND: Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor response to different therapy protocols is variable, with hypoxia known to be a major factor that negatively influences treatmen...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 September 2012
|
| In: |
Radiation oncology
Year: 2012, Jahrgang: 7 |
| ISSN: | 1748-717X |
| DOI: | 10.1186/1748-717X-7-157 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1748-717X-7-157
|
| Verfasserangaben: | Vasileios Askoxylakis, Julien Dinkel, Monika Eichinger, Bram Stieltjes, Gregor Sommer, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Annette Kopp-Schneider, Uwe Haberkorn, Peter E. Huber, Marc Bischof, Jürgen Debus and Christian Thieke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580060994 | ||
| 003 | DE-627 | ||
| 005 | 20220814220508.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180815s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1748-717X-7-157 |2 doi | |
| 035 | |a (DE-627)1580060994 | ||
| 035 | |a (DE-576)510060994 | ||
| 035 | |a (DE-599)BSZ510060994 | ||
| 035 | |a (OCoLC)1341016791 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Askoxylakis, Vasileios |d 1978- |e VerfasserIn |0 (DE-588)133302261 |0 (DE-627)69132753X |0 (DE-576)276112148 |4 aut | |
| 245 | 1 | 0 | |a Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer |b the HIL trial |c Vasileios Askoxylakis, Julien Dinkel, Monika Eichinger, Bram Stieltjes, Gregor Sommer, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Annette Kopp-Schneider, Uwe Haberkorn, Peter E. Huber, Marc Bischof, Jürgen Debus and Christian Thieke |
| 264 | 1 | |c 14 September 2012 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.08.2018 | ||
| 520 | |a BACKGROUND: Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor response to different therapy protocols is variable, with hypoxia known to be a major factor that negatively influences treatment effectiveness. Visualisation of tumor hypoxia prior to the use of modern radiation therapy strategies, such as intensity modulated radiation therapy (IMRT), might allow optimized dose applications to the target volume, leading to improvement of therapy outcome. (18)F-fluoromisonidazole dynamic positron emission tomography and computed tomography ((18) F-FMISO dPET-CT) and functional magnetic resonance imaging (functional MRI) are attractive options for imaging tumor hypoxia. METHODS/DESIGN: The HIL trial is a single centre study combining multimodal hypoxia imaging with (18) F-FMISO dPET-CT and functional MRI, with intensity modulated radiation therapy (IMRT) in patients with inoperable stage III NSCLC. 15 patients will be recruited in the study. All patients undergo initial FDG PET-CT and serial (18) F-FMISO dPET-CT and functional MRI before treatment, at week 5 of radiotherapy and 6 weeks post treatment. Radiation therapy is performed as inversely planned IMRT based on 4D-CT. DISCUSSION: Primary objectives of the trial are to characterize the correlation of (18) F-FMISO dPET-CT and functional MRI for tumor hypoxia imaging in NSCLC and evaluate possible effects of radiation therapy on tumor re-oxygenation. Further objectives include the generation of data regarding the prognostic value of (18) F-FMISO dPET-CT and functional MRI for locoregional control, progression free survival and overall survival of NSCLC treated with IMRT, which will form the basis for larger clinical trials focusing on possible interactions between tumor oxygenation and radiotherapy outcome. TRIAL REGISTRATION: The ClinicalTrials.gov protocol ID is NCT01617980. | ||
| 650 | 4 | |a Algorithms | |
| 650 | 4 | |a Carcinoma, Non-Small-Cell Lung | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Lung Neoplasms | |
| 650 | 4 | |a Magnetic Resonance Imaging | |
| 650 | 4 | |a Misonidazole | |
| 650 | 4 | |a Multimodal Imaging | |
| 650 | 4 | |a Neoplasm Staging | |
| 650 | 4 | |a Positron-Emission Tomography | |
| 650 | 4 | |a Radiation-Sensitizing Agents | |
| 650 | 4 | |a Radiotherapy Planning, Computer-Assisted | |
| 650 | 4 | |a Radiotherapy, Intensity-Modulated | |
| 650 | 4 | |a Salvage Therapy | |
| 650 | 4 | |a Tomography, X-Ray Computed | |
| 650 | 4 | |a Treatment Outcome | |
| 700 | 1 | |a Dinkel, Julien |d 1978- |e VerfasserIn |0 (DE-588)140755632 |0 (DE-627)621592773 |0 (DE-576)320647374 |4 aut | |
| 700 | 1 | |a Eichinger, Monika |d 1964- |e VerfasserIn |0 (DE-588)1049617525 |0 (DE-627)78269117X |0 (DE-576)172609712 |4 aut | |
| 700 | 1 | |a Strauss, Ludwig G. |d 1949-2013 |e VerfasserIn |0 (DE-588)1108137024 |0 (DE-627)863758835 |0 (DE-576)376098201 |4 aut | |
| 700 | 1 | |a Dimitrakopoulou-Strauss, Antonia |d 1963- |e VerfasserIn |0 (DE-588)1076688373 |0 (DE-627)835256901 |0 (DE-576)167486055 |4 aut | |
| 700 | 1 | |a Kopp-Schneider, Annette |e VerfasserIn |0 (DE-588)1119160545 |0 (DE-627)872460444 |0 (DE-576)178153206 |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Huber, Peter E. |d 1965- |e VerfasserIn |0 (DE-588)1074678869 |0 (DE-627)832350109 |0 (DE-576)442767803 |4 aut | |
| 700 | 1 | |a Bischof, Marc |d 1966- |e VerfasserIn |0 (DE-588)103275785X |0 (DE-627)739273825 |0 (DE-576)176908978 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Thieke, Christian |d 1970- |e VerfasserIn |0 (DE-588)129347396 |0 (DE-627)394260066 |0 (DE-576)297612417 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiation oncology |d London : BioMed Central, 2006 |g 7(2012) Artikel-Nummer 157, 7 Seiten |h Online-Ressource |w (DE-627)508725739 |w (DE-600)2224965-5 |w (DE-576)260614815 |x 1748-717X |7 nnas |a Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer the HIL trial |
| 773 | 1 | 8 | |g volume:7 |g year:2012 |g extent:7 |a Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer the HIL trial |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/1748-717X-7-157 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180815 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 129347396 |a Thieke, Christian |m 129347396:Thieke, Christian |d 910000 |d 911400 |e 910000PT129347396 |e 911400PT129347396 |k 0/910000/ |k 1/910000/911400/ |p 13 |y j | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 12 | ||
| 998 | |g 103275785X |a Bischof, Marc |m 103275785X:Bischof, Marc |d 910000 |d 911400 |e 910000PB103275785X |e 911400PB103275785X |k 0/910000/ |k 1/910000/911400/ |p 11 | ||
| 998 | |g 1074678869 |a Huber, Peter E. |m 1074678869:Huber, Peter E. |d 50000 |e 50000PH1074678869 |k 0/50000/ |p 10 | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 1119160545 |a Kopp-Schneider, Annette |m 1119160545:Kopp-Schneider, Annette |d 50000 |e 50000PK1119160545 |k 0/50000/ |p 8 | ||
| 998 | |g 1076688373 |a Dimitrakopoulou-Strauss, Antonia |m 1076688373:Dimitrakopoulou-Strauss, Antonia |d 910000 |d 911400 |e 910000PD1076688373 |e 911400PD1076688373 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 1108137024 |a Strauss, Ludwig G. |m 1108137024:Strauss, Ludwig G. |d 50000 |e 50000PS1108137024 |k 0/50000/ |p 6 | ||
| 998 | |g 1049617525 |a Eichinger, Monika |m 1049617525:Eichinger, Monika |d 50000 |e 50000PE1049617525 |k 0/50000/ |p 3 | ||
| 998 | |g 140755632 |a Dinkel, Julien |m 140755632:Dinkel, Julien |d 910000 |d 911400 |e 910000PD140755632 |e 911400PD140755632 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 133302261 |a Askoxylakis, Vasileios |m 133302261:Askoxylakis, Vasileios |d 910000 |d 911400 |e 910000PA133302261 |e 911400PA133302261 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580060994 |e 3022388349 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Vasileios","family":"Askoxylakis","display":"Askoxylakis, Vasileios","role":"aut"},{"given":"Julien","family":"Dinkel","display":"Dinkel, Julien","role":"aut"},{"display":"Eichinger, Monika","role":"aut","given":"Monika","family":"Eichinger"},{"role":"aut","display":"Strauss, Ludwig G.","given":"Ludwig G.","family":"Strauss"},{"role":"aut","display":"Dimitrakopoulou-Strauss, Antonia","family":"Dimitrakopoulou-Strauss","given":"Antonia"},{"family":"Kopp-Schneider","given":"Annette","display":"Kopp-Schneider, Annette","role":"aut"},{"role":"aut","display":"Haberkorn, Uwe","family":"Haberkorn","given":"Uwe"},{"display":"Huber, Peter E.","role":"aut","given":"Peter E.","family":"Huber"},{"role":"aut","display":"Bischof, Marc","family":"Bischof","given":"Marc"},{"display":"Debus, Jürgen","role":"aut","family":"Debus","given":"Jürgen"},{"display":"Thieke, Christian","role":"aut","given":"Christian","family":"Thieke"}],"language":["eng"],"id":{"doi":["10.1186/1748-717X-7-157"],"eki":["1580060994"]},"note":["Gesehen am 15.08.2018"],"relHost":[{"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer the HIL trialRadiation oncology","part":{"text":"7(2012) Artikel-Nummer 157, 7 Seiten","year":"2012","volume":"7","extent":"7"},"note":["Gesehen am 06.09.10"],"id":{"eki":["508725739"],"zdb":["2224965-5"],"issn":["1748-717X"]},"pubHistory":["1.2006 -"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2006","publisher":"BioMed Central","dateIssuedDisp":"2006-","publisherPlace":"London"}],"recId":"508725739","title":[{"title":"Radiation oncology","title_sort":"Radiation oncology"}]}],"name":{"displayForm":["Vasileios Askoxylakis, Julien Dinkel, Monika Eichinger, Bram Stieltjes, Gregor Sommer, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Annette Kopp-Schneider, Uwe Haberkorn, Peter E. Huber, Marc Bischof, Jürgen Debus and Christian Thieke"]},"origin":[{"dateIssuedDisp":"14 September 2012","dateIssuedKey":"2012"}],"physDesc":[{"extent":"7 S."}],"title":[{"title":"Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer","title_sort":"Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer","subtitle":"the HIL trial"}],"recId":"1580060994"} | ||
| SRT | |a ASKOXYLAKIMULTIMODAL1420 | ||