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SNEVhPrp19/hPso4 regulates adipogenesis of human adipose stromal cells

Summary Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiat...

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Bibliographic Details
Main Authors: Khan, Abdulhameed (Author) , Dellago, Hanna (Author) , Scheideler, Marcel (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Stem cell reports
Year: 2016, Volume: 8, Issue: 1, Pages: 21-29
ISSN:2213-6711
DOI:10.1016/j.stemcr.2016.12.001
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.stemcr.2016.12.001
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2213671116302776
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Author Notes:Abdulhameed Khan, Hanna Dellago, Lucia Terlecki-Zaniewicz, Michael Karbiener, Sylvia Weilner, Florian Hildner, Viktoria Steininger, Christian Gabriel, Christoph Mück, Pidder Jansen-Dürr, Ara Hacobian, Marcel Scheideler, Regina Grillari-Voglauer, Markus Schosserer, Johannes Grillari
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Summary:Summary Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process.
Item Description:Available online 29 December 2016
Gesehen am 15.08.2018
Physical Description:Online Resource
ISSN:2213-6711
DOI:10.1016/j.stemcr.2016.12.001

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