Applying microdroplets as sensors for label-free detection of chemical reactions
Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quan...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 Jan 2012
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| In: |
Lab on a chip
Year: 2012, Jahrgang: 12, Heft: 5, Pages: 916-922 |
| ISSN: | 1473-0189 |
| DOI: | 10.1039/C2LC20971C |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1039/C2LC20971C Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc20971c 
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| Verfasserangaben: | Tobias W. Hofmann, Siegfried Hänselmann, Jan-Wilhelm Janiesch, Anne Rademacher, Christian H.J. Böhm |
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| 520 | |a Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level. | ||
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