F2A sequence linking MGMT P140K and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells

Chemoprotection of haematopoietic stem cells (HSCs) by gene therapeutic transfer of drug-resistance genes represents the encouraging approach to prevent myelosuppression, which is one of the most severe side effects in tumor therapy. Thus, we cloned and evaluated six different bicistronic lentiviral...

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Bibliographic Details

Main Authors:	Maier, Patrick (Author) , Heckmann, Doreen (Author) , Maier-Laufs, Stephanie (Author) , Wenz, Frederik (Author)
Format:	Article (Journal)
Language:	English
Published:	05 October 2012
In:	Cancer gene therapy Year: 2012, Volume: 19, Issue: 11, Pages: 802-810
ISSN:	1476-5500
DOI:	10.1038/cgt.2012.67
Online Access:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/cgt.2012.67 Verlag, Volltext: https://www.nature.com/articles/cgt201267
Author Notes:	P. Maier, D. Heckmann, I. Spier, S. Laufs, M. Zucknick, H. Allgayer, S. Fruehauf, W.J. Zeller and F. Wenz