Buchumschlag

Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo

The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer’s disease. Here, we studied whether the lack of APP affects the synaptic properties in the dentate gyrus by measuring granule cell field potentials evoked by perforant path stimulation in anesthetized 9-11-mont...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jedlička, Peter (VerfasserIn) , Tschäpe, Jakob-Andreas (VerfasserIn) , Hick, Meike (VerfasserIn) , Müller, Ulrike C. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2012
In: Experimental brain research
Year: 2011, Jahrgang: 217, Heft: 3, Pages: 441-447
ISSN:1432-1106
DOI:10.1007/s00221-011-2911-9
Online-Zugang:Verlag, Volltext: https://doi.org/10.1007/s00221-011-2911-9
Verlag, Volltext: http://dx.doi.org/10.1007/s00221-011-2911-9
Volltext
Verfasserangaben:Peter Jedlicka, Mirka Owen, Matej Vnencak, Jakob-A. Tschäpe, Meike Hick, Ulrike C. Müller, Thomas Deller

MARC

LEADER 00000caa a2200000 c 4500
001 158018541X
003 DE-627
005 20230427065648.0
007 cr uuu---uuuuu
008 180820r20122011xx |||||o 00| ||eng c
024 7 |a 10.1007/s00221-011-2911-9  |2 doi 
035 |a (DE-627)158018541X 
035 |a (DE-576)51018541X 
035 |a (DE-599)BSZ51018541X 
035 |a (OCoLC)1341017042 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Jedlička, Peter  |e VerfasserIn  |0 (DE-588)1077894422  |0 (DE-627)83771124X  |0 (DE-576)447087843  |4 aut 
245 1 0 |a Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo  |c Peter Jedlicka, Mirka Owen, Matej Vnencak, Jakob-A. Tschäpe, Meike Hick, Ulrike C. Müller, Thomas Deller 
264 1 |c 2012 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Published online 11 November 2011 
500 |a Gesehen am 20.08.2018 
520 |a The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer’s disease. Here, we studied whether the lack of APP affects the synaptic properties in the dentate gyrus by measuring granule cell field potentials evoked by perforant path stimulation in anesthetized 9-11-month-old APP-deficient mice in vivo. We found decreased paired-pulse facilitation, indicating altered presynaptic short-term plasticity in the APP-deficient dentate gyrus. In contrast, excitatory synaptic strength and granule cell firing were unchanged in APP knockout mice. Likewise, long-term potentiation (LTP) induced by a theta-burst stimulation protocol was not impaired in the absence of APP. These findings suggest that the deletion of APP may affect presynaptic plasticity of synaptic transmission at the perforant path-granule cell synapse but leaves synaptic efficacy intact and LTP preserved, possibly due to functional redundancy within the APP gene family. 
534 |c 2011 
650 4 |a Alzheimer’s disease 
650 4 |a Granule cell 
650 4 |a Long-term potentiation 
650 4 |a Perforant path 
650 4 |a Synaptic plasticity 
700 1 |a Tschäpe, Jakob-Andreas  |e VerfasserIn  |0 (DE-588)1020648457  |0 (DE-627)691291829  |0 (DE-576)361715005  |4 aut 
700 1 |a Hick, Meike  |e VerfasserIn  |0 (DE-588)1025145186  |0 (DE-627)721335616  |0 (DE-576)370013697  |4 aut 
700 1 |a Müller, Ulrike C.  |d 1960-  |e VerfasserIn  |0 (DE-588)1020647965  |0 (DE-627)691291403  |0 (DE-576)361723210  |4 aut 
773 0 8 |i Enthalten in  |t Experimental brain research  |d Berlin : Springer, 1966  |g 217(2012), 3, Seite 441-447  |h Online-Ressource  |w (DE-627)253723159  |w (DE-600)1459099-2  |w (DE-576)072372753  |x 1432-1106  |7 nnas  |a Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo 
773 1 8 |g volume:217  |g year:2012  |g number:3  |g pages:441-447  |g extent:7  |a Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo 
856 4 0 |u https://doi.org/10.1007/s00221-011-2911-9  |x Verlag  |3 Volltext 
856 4 0 |u http://dx.doi.org/10.1007/s00221-011-2911-9  |x Verlag  |x Resolving-System  |3 Volltext 
951 |a AR 
992 |a 20180820 
993 |a Article 
994 |a 2012 
998 |g 1020647965  |a Müller, Ulrike C.  |m 1020647965:Müller, Ulrike C.  |d 160000  |d 160100  |e 160000PM1020647965  |e 160100PM1020647965  |k 0/160000/  |k 1/160000/160100/  |p 6 
998 |g 1025145186  |a Hick, Meike  |m 1025145186:Hick, Meike  |d 160000  |d 160100  |e 160000PH1025145186  |e 160100PH1025145186  |k 0/160000/  |k 1/160000/160100/  |p 5 
999 |a KXP-PPN158018541X  |e 3022601719 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"7 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York","publisher":"Springer","dateIssuedKey":"1966","dateIssuedDisp":"1966-"}],"id":{"issn":["1432-1106"],"eki":["253723159"],"zdb":["1459099-2"]},"pubHistory":["1.1966 -"],"part":{"text":"217(2012), 3, Seite 441-447","volume":"217","extent":"7","year":"2012","pages":"441-447","issue":"3"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 11.10.05"],"disp":"Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivoExperimental brain research","language":["eng"],"recId":"253723159","title":[{"title":"Experimental brain research","title_sort":"Experimental brain research"}]}],"name":{"displayForm":["Peter Jedlicka, Mirka Owen, Matej Vnencak, Jakob-A. Tschäpe, Meike Hick, Ulrike C. Müller, Thomas Deller"]},"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"id":{"doi":["10.1007/s00221-011-2911-9"],"eki":["158018541X"]},"note":["Published online 11 November 2011","Gesehen am 20.08.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"158018541X","person":[{"family":"Jedlička","given":"Peter","roleDisplay":"VerfasserIn","display":"Jedlička, Peter","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Tschäpe, Jakob-Andreas","role":"aut","family":"Tschäpe","given":"Jakob-Andreas"},{"given":"Meike","family":"Hick","role":"aut","roleDisplay":"VerfasserIn","display":"Hick, Meike"},{"given":"Ulrike C.","family":"Müller","role":"aut","display":"Müller, Ulrike C.","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo","title":"Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo"}]} 
SRT |a JEDLICKAPEFUNCTIONAL2012 

Ähnliche Einträge