Neural stem cells for spinal cord repair
Spinal cord injury (SCI) causes the irreversible loss of spinal cord parenchyma including astroglia, oligodendroglia and neurons. In particular, severe injuries can lead to an almost complete neural cell loss at the lesion site and structural and functional recovery might only be accomplished by app...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
Cell & tissue research
Year: 2012, Jahrgang: 349, Heft: 1, Pages: 349-362 |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/s00441-012-1363-2 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00441-012-1363-2 Verlag, Volltext: https://doi.org/10.1007/s00441-012-1363-2 
|
| Verfasserangaben: | Beatrice Sandner, Peter Prang, Francisco J. Rivera, Ludwig Aigner, Armin Blesch, Norbert Weidner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580207324 | ||
| 003 | DE-627 | ||
| 005 | 20220814224513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180820s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00441-012-1363-2 |2 doi | |
| 035 | |a (DE-627)1580207324 | ||
| 035 | |a (DE-576)510207324 | ||
| 035 | |a (DE-599)BSZ510207324 | ||
| 035 | |a (OCoLC)1341017231 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sandner, Beatrice |e VerfasserIn |0 (DE-588)1063824834 |0 (DE-627)812639715 |0 (DE-576)423260693 |4 aut | |
| 245 | 1 | 0 | |a Neural stem cells for spinal cord repair |c Beatrice Sandner, Peter Prang, Francisco J. Rivera, Ludwig Aigner, Armin Blesch, Norbert Weidner |
| 264 | 1 | |c 2012 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.08.2018 | ||
| 520 | |a Spinal cord injury (SCI) causes the irreversible loss of spinal cord parenchyma including astroglia, oligodendroglia and neurons. In particular, severe injuries can lead to an almost complete neural cell loss at the lesion site and structural and functional recovery might only be accomplished by appropriate cell and tissue replacement. Stem cells have the capacity to differentiate into all relevant neural cell types necessary to replace degenerated spinal cord tissue and can now be obtained from virtually any stage of development. Within the last two decades, many in vivo studies in small animal models of SCI have demonstrated that stem cell transplantation can promote morphological and, in some cases, functional recovery via various mechanisms including remyelination, axon growth and regeneration, or neuronal replacement. However, only two well-documented neural-stem-cell-based transplantation strategies have moved to phase I clinical trials to date. This review aims to provide an overview about the current status of preclinical and clinical neural stem cell transplantation and discusses future perspectives in the field. | ||
| 650 | 4 | |a Axon | |
| 650 | 4 | |a Regeneration | |
| 650 | 4 | |a Remyelination | |
| 650 | 4 | |a Stem cell | |
| 650 | 4 | |a Transplantation | |
| 700 | 1 | |a Prang, Peter |d 1972- |e VerfasserIn |0 (DE-588)123737427 |0 (DE-627)706412036 |0 (DE-576)302555757 |4 aut | |
| 700 | 1 | |a Rivera, Francisco J. |e VerfasserIn |0 (DE-588)1156432243 |0 (DE-627)1019261609 |0 (DE-576)502186682 |4 aut | |
| 700 | 1 | |a Blesch, Armin |d 1955- |e VerfasserIn |0 (DE-588)1054609381 |0 (DE-627)791643417 |0 (DE-576)173769993 |4 aut | |
| 700 | 1 | |a Weidner, Norbert |e VerfasserIn |0 (DE-588)1035265907 |0 (DE-627)747116326 |0 (DE-576)176492577 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell & tissue research |d Berlin : Springer, 1974 |g 349(2012), 1, Seite 349-362 |h Online-Ressource |w (DE-627)253390516 |w (DE-600)1458496-7 |w (DE-576)07228353X |x 1432-0878 |7 nnas |a Neural stem cells for spinal cord repair |
| 773 | 1 | 8 | |g volume:349 |g year:2012 |g number:1 |g pages:349-362 |g extent:14 |a Neural stem cells for spinal cord repair |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00441-012-1363-2 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00441-012-1363-2 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180820 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1035265907 |a Weidner, Norbert |m 1035265907:Weidner, Norbert |d 910000 |d 911460 |e 910000PW1035265907 |e 911460PW1035265907 |k 0/910000/ |k 1/910000/911460/ |p 6 |y j | ||
| 998 | |g 1054609381 |a Blesch, Armin |m 1054609381:Blesch, Armin |d 910000 |d 911460 |e 910000PB1054609381 |e 911460PB1054609381 |k 0/910000/ |k 1/910000/911460/ |p 5 | ||
| 998 | |g 123737427 |a Prang, Peter |m 123737427:Prang, Peter |d 910000 |d 911460 |e 910000PP123737427 |e 911460PP123737427 |k 0/910000/ |k 1/910000/911460/ |p 2 | ||
| 998 | |g 1063824834 |a Sandner, Beatrice |m 1063824834:Sandner, Beatrice |d 910000 |d 911460 |e 910000PS1063824834 |e 911460PS1063824834 |k 0/910000/ |k 1/910000/911460/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580207324 |e 302265054X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"language":["eng"],"part":{"issue":"1","extent":"14","pages":"349-362","text":"349(2012), 1, Seite 349-362","year":"2012","volume":"349"},"note":["Gesehen am 24.04.25"],"pubHistory":["Volume 148, issue 1 (March 1974)-"],"disp":"Neural stem cells for spinal cord repairCell & tissue research","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Cell and tissue research"}],"recId":"253390516","title":[{"title":"Cell & tissue research","title_sort":"Cell & tissue research"}],"id":{"zdb":["1458496-7"],"issn":["1432-0878"],"eki":["253390516"]},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1974","publisherPlace":"Berlin ; Heidelberg","publisher":"Springer","dateIssuedDisp":"1974-"}]}],"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"title":[{"title_sort":"Neural stem cells for spinal cord repair","title":"Neural stem cells for spinal cord repair"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"14 S."}],"id":{"doi":["10.1007/s00441-012-1363-2"],"eki":["1580207324"]},"person":[{"family":"Sandner","role":"aut","display":"Sandner, Beatrice","given":"Beatrice"},{"role":"aut","family":"Prang","given":"Peter","display":"Prang, Peter"},{"family":"Rivera","role":"aut","display":"Rivera, Francisco J.","given":"Francisco J."},{"given":"Armin","display":"Blesch, Armin","family":"Blesch","role":"aut"},{"display":"Weidner, Norbert","given":"Norbert","family":"Weidner","role":"aut"}],"recId":"1580207324","note":["Gesehen am 20.08.2018"],"name":{"displayForm":["Beatrice Sandner, Peter Prang, Francisco J. Rivera, Ludwig Aigner, Armin Blesch, Norbert Weidner"]},"language":["eng"]} | ||
| SRT | |a SANDNERBEANEURALSTEM2012 | ||