The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery
Objective: Patients undergoing cardiac surgery are at risk for postoperative cognitive dysfunction (POCD). Evaluating preoperative risk factors represents 1 possible way to minimize the postoperative risk of cognitive dysfunction. We investigated marked deterioration in cholinergic neurotransmission...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
The journal of thoracic and cardiovascular surgery
Year: 2013, Jahrgang: 145, Heft: 3, Pages: 805-811 |
| ISSN: | 1097-685X |
| DOI: | 10.1016/j.jtcvs.2012.07.043 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jtcvs.2012.07.043 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022522312008872 
|
| Verfasserangaben: | Konstanze Plaschke, Steffen Hauth, Claudia Jansen, Thomas Bruckner, Christoph Schramm, Matthias Karck, and Jürgen Kopitz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580264700 | ||
| 003 | DE-627 | ||
| 005 | 20240606190802.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180822s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jtcvs.2012.07.043 |2 doi | |
| 035 | |a (DE-627)1580264700 | ||
| 035 | |a (DE-576)510264700 | ||
| 035 | |a (DE-599)BSZ510264700 | ||
| 035 | |a (OCoLC)1341017097 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Plaschke, Konstanze |e VerfasserIn |0 (DE-588)1058094637 |0 (DE-627)79637919X |0 (DE-576)171750365 |4 aut | |
| 245 | 1 | 4 | |a The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery |c Konstanze Plaschke, Steffen Hauth, Claudia Jansen, Thomas Bruckner, Christoph Schramm, Matthias Karck, and Jürgen Kopitz |
| 264 | 1 | |c 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 27 August 2012 | ||
| 500 | |a Gesehen am 22.08.2018 | ||
| 520 | |a Objective: Patients undergoing cardiac surgery are at risk for postoperative cognitive dysfunction (POCD). Evaluating preoperative risk factors represents 1 possible way to minimize the postoperative risk of cognitive dysfunction. We investigated marked deterioration in cholinergic neurotransmission as 1 such potential risk factor for transient and long-lasting POCD. Serum anticholinergic activity (SAA) has already been described as a risk factor for developing delirium in an elderly study population. However, the role of SAA for long-lasting POCD is unknown. Methods: Following local ethics board approval and written informed consent, we recruited a cohort of patients aged ≥ 55 years undergoing cardiac surgery. Before surgery, levels of SAA were measured and a battery of neuropsychologic tests (NPTs) was applied. S100 calcium binding protein ß concentration was measured intraoperatively. Pre-, intra-, and postoperative patient-specific characteristics were recorded. The NPTs were repeated 3 months after hospital discharge to evaluate 3-month POCD. A group of nonsurgical patients (n = 34) was recruited as control subjects to adjust NPT scores, using reliable methods for the change index. Logistic multivariate regression was used to evaluate independent predictors of POCD. Results: One hundred fifty-four patients were screened before surgery, and 117 completed the second NPT. POCD was identified in 25.6% of patients. In contrast to intraoperatively increased S100 calcium binding protein ß, preoperative SAA was not associated with POCD following adjustment for covariates. Conclusions: Preoperatively increased SAA did not predict POCD 3 months after cardiac surgery. | ||
| 700 | 1 | |a Hauth, Steffen |d 1977- |e VerfasserIn |0 (DE-588)1021669709 |0 (DE-627)715826069 |0 (DE-576)362845530 |4 aut | |
| 700 | 1 | |a Jansen, Claudia |d 1965- |e VerfasserIn |0 (DE-588)132305119 |0 (DE-627)521412161 |0 (DE-576)299063127 |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Schramm, Christoph |e VerfasserIn |0 (DE-588)1071861395 |0 (DE-627)826484778 |0 (DE-576)433375507 |4 aut | |
| 700 | 1 | |a Karck, Matthias |d 1961- |e VerfasserIn |0 (DE-588)130833525 |0 (DE-627)505909340 |0 (DE-576)298366169 |4 aut | |
| 700 | 1 | |a Kopitz, Jürgen |e VerfasserIn |0 (DE-588)1033923397 |0 (DE-627)743674472 |0 (DE-576)16530393X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of thoracic and cardiovascular surgery |d Amsterdam : Elsevier, 1959 |g 145(2013), 3, Seite 805-811 |h Online-Ressource |w (DE-627)311746586 |w (DE-600)2007600-9 |w (DE-576)090892712 |x 1097-685X |7 nnas |a The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery |
| 773 | 1 | 8 | |g volume:145 |g year:2013 |g number:3 |g pages:805-811 |g extent:7 |a The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jtcvs.2012.07.043 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0022522312008872 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180822 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1033923397 |a Kopitz, Jürgen |m 1033923397:Kopitz, Jürgen |d 910000 |d 912000 |e 910000PK1033923397 |e 912000PK1033923397 |k 0/910000/ |k 1/910000/912000/ |p 7 |y j | ||
| 998 | |g 130833525 |a Karck, Matthias |m 130833525:Karck, Matthias |d 910000 |d 910200 |e 910000PK130833525 |e 910200PK130833525 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 1071861395 |a Schramm, Christoph |m 1071861395:Schramm, Christoph |d 910000 |d 910300 |e 910000PS1071861395 |e 910300PS1071861395 |k 0/910000/ |k 1/910000/910300/ |p 5 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |d 910000 |d 999701 |e 910000PB136046215 |e 999701PB136046215 |k 0/910000/ |k 1/910000/999701/ |p 4 | ||
| 998 | |g 132305119 |a Jansen, Claudia |m 132305119:Jansen, Claudia |d 910000 |d 911100 |e 910000PJ132305119 |e 911100PJ132305119 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 998 | |g 1021669709 |a Hauth, Steffen |m 1021669709:Hauth, Steffen |d 910000 |d 910300 |e 910000PH1021669709 |e 910300PH1021669709 |k 0/910000/ |k 1/910000/910300/ |p 2 | ||
| 998 | |g 1058094637 |a Plaschke, Konstanze |m 1058094637:Plaschke, Konstanze |d 910000 |d 910300 |e 910000PP1058094637 |e 910300PP1058094637 |k 0/910000/ |k 1/910000/910300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580264700 |e 3022911572 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Available online 27 August 2012","Gesehen am 22.08.2018"],"title":[{"title_sort":"influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery","title":"The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery"}],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"person":[{"family":"Plaschke","given":"Konstanze","role":"aut","display":"Plaschke, Konstanze"},{"display":"Hauth, Steffen","family":"Hauth","given":"Steffen","role":"aut"},{"display":"Jansen, Claudia","family":"Jansen","given":"Claudia","role":"aut"},{"role":"aut","given":"Thomas","family":"Bruckner","display":"Bruckner, Thomas"},{"family":"Schramm","given":"Christoph","role":"aut","display":"Schramm, Christoph"},{"display":"Karck, Matthias","given":"Matthias","role":"aut","family":"Karck"},{"display":"Kopitz, Jürgen","family":"Kopitz","given":"Jürgen","role":"aut"}],"relHost":[{"id":{"issn":["1097-685X"],"eki":["311746586"],"zdb":["2007600-9"]},"part":{"volume":"145","year":"2013","issue":"3","extent":"7","text":"145(2013), 3, Seite 805-811","pages":"805-811"},"pubHistory":["Volume 38, number 1 (July 1959)-"],"titleAlt":[{"title":"JTCVS"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 19.07.2023"],"title":[{"subtitle":"official publication of the American Association for Thoracic Surgery and the Western Thoracic Surgical Association","title_sort":"journal of thoracic and cardiovascular surgery","title":"The journal of thoracic and cardiovascular surgery"}],"origin":[{"publisherPlace":"Amsterdam ; St. Louis, Mo. ; Stanford, Calif.","dateIssuedDisp":"[1959]-","publisher":"Elsevier ; Mosby ; HighWire Press"}],"disp":"The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgeryThe journal of thoracic and cardiovascular surgery","physDesc":[{"extent":"Online-Ressource"}],"recId":"311746586"}],"physDesc":[{"extent":"7 S."}],"recId":"1580264700","id":{"doi":["10.1016/j.jtcvs.2012.07.043"],"eki":["1580264700"]},"name":{"displayForm":["Konstanze Plaschke, Steffen Hauth, Claudia Jansen, Thomas Bruckner, Christoph Schramm, Matthias Karck, and Jürgen Kopitz"]}} | ||
| SRT | |a PLASCHKEKOINFLUENCEO2013 | ||