Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform
The synthesis and characterization of a novel dinucleating ligand L (L=4,11-dimethyl-1,8-bis2-[N-(di-2-pyridylmethyl)amino]ethylcyclam) and its μ-oxo-bridged diferric complex [(H2L)FeIII2(O)(Cl)4]2+ are reported. This diiron(III) complex is the first example of a truly functional purple acid phospha...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 January 2012
|
| In: |
Chemistry - a European journal
Year: 2012, Jahrgang: 18, Heft: 6, Pages: 1700-1710 |
| ISSN: | 1521-3765 |
| DOI: | 10.1002/chem.201100229 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/chem.201100229 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201100229 
|
| Verfasserangaben: | Peter Comba, Lawrence R. Gahan, Graeme R. Hanson, Valeriu Mereacre, Christopher J. Noble, Annie K. Powell, Ion Prisecaru, Gerhard Schenk and Marta Zajaczkowski‐Fischer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580269613 | ||
| 003 | DE-627 | ||
| 005 | 20230427065652.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180822s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/chem.201100229 |2 doi | |
| 035 | |a (DE-627)1580269613 | ||
| 035 | |a (DE-576)510269613 | ||
| 035 | |a (DE-599)BSZ510269613 | ||
| 035 | |a (OCoLC)1341017249 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Comba, Peter |d 1953- |e VerfasserIn |0 (DE-588)122976843 |0 (DE-627)082271712 |0 (DE-576)160608988 |4 aut | |
| 245 | 1 | 0 | |a Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform |c Peter Comba, Lawrence R. Gahan, Graeme R. Hanson, Valeriu Mereacre, Christopher J. Noble, Annie K. Powell, Ion Prisecaru, Gerhard Schenk and Marta Zajaczkowski‐Fischer |
| 264 | 1 | |c 10 January 2012 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.08.2018 | ||
| 520 | |a The synthesis and characterization of a novel dinucleating ligand L (L=4,11-dimethyl-1,8-bis2-[N-(di-2-pyridylmethyl)amino]ethylcyclam) and its μ-oxo-bridged diferric complex [(H2L)FeIII2(O)(Cl)4]2+ are reported. This diiron(III) complex is the first example of a truly functional purple acid phosphatase (PAP) mimic as it accelerates the hydrolysis of the activated phosphomonoester 2,4-dinitrophenyl phosphate (DNPP). The spectroscopic and kinetic data indicate that only substrates that are monodentately bound to one of the two ferric ions can be attacked by a suitable nucleophile. This is, most probably, a terminal iron(III)-bound hydroxide. DFT calculations support this assumption and also highlight the importance of secondary interactions, exerted by the protonated cyclam platform, for the positioning and activation of the iron(III)-bound substrate. Similar effects are postulated in the native enzyme but addressed in PAP mimics for the first time. | ||
| 650 | 4 | |a bioinorganic chemistry | |
| 650 | 4 | |a enzymes | |
| 650 | 4 | |a hydrogen bonds | |
| 650 | 4 | |a hydrolysis | |
| 650 | 4 | |a iron | |
| 700 | 1 | |a Zajaczkowski-Fischer, Marta |e VerfasserIn |0 (DE-588)142860042 |0 (DE-627)640548679 |0 (DE-576)333746961 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemistry - a European journal |d Weinheim : Wiley-VCH, 1995 |g 18(2012), 6, Seite 1700-1710 |h Online-Ressource |w (DE-627)270935193 |w (DE-600)1478547-X |w (DE-576)078707404 |x 1521-3765 |7 nnas |a Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform |
| 773 | 1 | 8 | |g volume:18 |g year:2012 |g number:6 |g pages:1700-1710 |g extent:11 |a Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/chem.201100229 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201100229 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180822 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 142860042 |a Zajaczkowski-Fischer, Marta |m 142860042:Zajaczkowski-Fischer, Marta |d 120000 |d 120200 |e 120000PZ142860042 |e 120200PZ142860042 |k 0/120000/ |k 1/120000/120200/ |p 9 |y j | ||
| 998 | |g 122976843 |a Comba, Peter |m 122976843:Comba, Peter |d 120000 |d 120200 |e 120000PC122976843 |e 120200PC122976843 |k 0/120000/ |k 1/120000/120200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580269613 |e 3022919107 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1995 -"],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 27. Februar 2017"],"recId":"270935193","part":{"text":"18(2012), 6, Seite 1700-1710","year":"2012","extent":"11","pages":"1700-1710","volume":"18","issue":"6"},"id":{"zdb":["1478547-X"],"eki":["270935193"],"issn":["1521-3765"],"doi":["10.1002/(ISSN)1521-3765"]},"disp":"Monoesterase activity of a purple acid phosphatase mimic with a cyclam platformChemistry - a European journal","language":["eng"],"origin":[{"dateIssuedDisp":"1995-","publisher":"Wiley-VCH","dateIssuedKey":"1995","publisherPlace":"Weinheim"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Chemistry - a European journal","title_sort":"Chemistry - a European journal"}]}],"name":{"displayForm":["Peter Comba, Lawrence R. Gahan, Graeme R. Hanson, Valeriu Mereacre, Christopher J. Noble, Annie K. Powell, Ion Prisecaru, Gerhard Schenk and Marta Zajaczkowski‐Fischer"]},"id":{"eki":["1580269613"],"doi":["10.1002/chem.201100229"]},"physDesc":[{"extent":"11 S."}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"10 January 2012"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","given":"Peter","display":"Comba, Peter","family":"Comba"},{"display":"Zajaczkowski-Fischer, Marta","given":"Marta","roleDisplay":"VerfasserIn","role":"aut","family":"Zajaczkowski-Fischer"}],"title":[{"title":"Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform","title_sort":"Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1580269613","note":["Gesehen am 22.08.2018"]} | ||
| SRT | |a COMBAPETERMONOESTERA1020 | ||