Phosphatase reactivity of a dicopper(II) complex of a patellamide derivative - possible biological functions of cyclic pseudopeptides
A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu2(H2Pat1)(μ-OH)(OH2)2]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
Chemical communications
Year: 2012, Jahrgang: 48, Heft: 75, Pages: 9364-9366 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C2CC34836E |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1039/C2CC34836E Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc34836e 
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| Verfasserangaben: | Peter Comba, Lawrence R. Gahan, Graeme R. Hanson and Michael Westphal |
MARC
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| 520 | |a A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu2(H2Pat1)(μ-OH)(OH2)2]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO2 into CO32−. This complex is shown here to function as a phosphatase mimic, suggesting that the so far unknown biological function of these macrocycles within the ascidians may involve phosphoester hydrolysis. | ||
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