Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species
The incidence of azole resistance in Aspergillus species has increased over the past years, most importantly for Aspergillus fumigatus. This is partially attributable to the global spread of only a few resistance alleles through the environment. Secondary resistance is a significant clinical concern...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 13, 2017
|
| In: |
Clinical microbiology reviews
Year: 2017, Jahrgang: 30, Heft: 4, Pages: 1065-1091 |
| ISSN: | 1098-6618 |
| DOI: | 10.1128/CMR.00095-16 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1128/CMR.00095-16 Verlag, Volltext: https://cmr-asm-org.ezproxy.medma.uni-heidelberg.de/content/30/4/1065 
|
| Verfasserangaben: | Anna Dudakova, Birgit Spiess, Marut Tangwattanachuleeporn, Christoph Sasse, Dieter Buchheidt, Michael Weig, Uwe Groß, Oliver Bader |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580301487 | ||
| 003 | DE-627 | ||
| 005 | 20230427065654.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180822s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/CMR.00095-16 |2 doi | |
| 035 | |a (DE-627)1580301487 | ||
| 035 | |a (DE-576)510301487 | ||
| 035 | |a (DE-599)BSZ510301487 | ||
| 035 | |a (OCoLC)1341017273 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dudakova, Anna |d 1985- |e VerfasserIn |0 (DE-588)1034652303 |0 (DE-627)746142161 |0 (DE-576)382292081 |4 aut | |
| 245 | 1 | 0 | |a Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species |c Anna Dudakova, Birgit Spiess, Marut Tangwattanachuleeporn, Christoph Sasse, Dieter Buchheidt, Michael Weig, Uwe Groß, Oliver Bader |
| 264 | 1 | |c September 13, 2017 | |
| 300 | |a 27 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.08.2018 | ||
| 520 | |a The incidence of azole resistance in Aspergillus species has increased over the past years, most importantly for Aspergillus fumigatus. This is partially attributable to the global spread of only a few resistance alleles through the environment. Secondary resistance is a significant clinical concern, as invasive aspergillosis with drug-susceptible strains is already difficult to treat, and exclusion of azole-based antifungals from prophylaxis or first-line treatment of invasive aspergillosis in high-risk patients would dramatically limit drug choices, thus increasing mortality rates for immunocompromised patients. Management options for invasive aspergillosis caused by azole-resistant A. fumigatus strains were recently reevaluated by an international expert panel, which concluded that drug resistance testing of cultured isolates is highly indicated when antifungal therapy is intended. In geographical regions with a high environmental prevalence of azole-resistant strains, initial therapy should be guided by such analyses. More environmental and clinical screening studies are therefore needed to generate the local epidemiologic data if such measures are to be implemented on a sound basis. Here we propose a first workflow for evaluating isolates from screening studies, and we compile the MIC values correlating with individual amino acid substitutions in the products of cyp51 genes for interpretation of DNA sequencing data, especially in the absence of cultured isolates. | ||
| 700 | 1 | |a Spiess, Birgit |d 1972- |e VerfasserIn |0 (DE-588)1028287496 |0 (DE-627)730538699 |0 (DE-576)37578764X |4 aut | |
| 700 | 1 | |a Buchheidt, Dieter |d 1955- |e VerfasserIn |0 (DE-588)1028287461 |0 (DE-627)730538621 |0 (DE-576)375787380 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical microbiology reviews |d Washington, DC : Soc., 1988 |g 30(2017), 4, Seite 1065-1091 |h Online-Ressource |w (DE-627)306357801 |w (DE-600)1497041-7 |w (DE-576)097188611 |x 1098-6618 |7 nnas |a Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species |
| 773 | 1 | 8 | |g volume:30 |g year:2017 |g number:4 |g pages:1065-1091 |g extent:27 |a Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1128/CMR.00095-16 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://cmr-asm-org.ezproxy.medma.uni-heidelberg.de/content/30/4/1065 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180822 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1028287461 |a Buchheidt, Dieter |m 1028287461:Buchheidt, Dieter |d 60000 |d 61200 |e 60000PB1028287461 |e 61200PB1028287461 |k 0/60000/ |k 1/60000/61200/ |p 5 | ||
| 998 | |g 1028287496 |a Spiess, Birgit |m 1028287496:Spiess, Birgit |d 60000 |d 61200 |e 60000PS1028287496 |e 61200PS1028287496 |k 0/60000/ |k 1/60000/61200/ |p 2 | ||
| 999 | |a KXP-PPN1580301487 |e 302296773X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Anna Dudakova, Birgit Spiess, Marut Tangwattanachuleeporn, Christoph Sasse, Dieter Buchheidt, Michael Weig, Uwe Groß, Oliver Bader"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"September 13, 2017"}],"id":{"doi":["10.1128/CMR.00095-16"],"eki":["1580301487"]},"physDesc":[{"extent":"27 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1098-6618"],"zdb":["1497041-7"],"eki":["306357801"]},"origin":[{"dateIssuedDisp":"1988-","publisher":"Soc.","dateIssuedKey":"1988","publisherPlace":"Washington, DC"}],"name":{"displayForm":["American Society for Microbiology"]},"part":{"year":"2017","pages":"1065-1091","issue":"4","volume":"30","text":"30(2017), 4, Seite 1065-1091","extent":"27"},"pubHistory":["1.1988 -"],"language":["eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"American Society for Microbiology","role":"isb"}],"recId":"306357801","disp":"Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus speciesClinical microbiology reviews","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 07.06.2021","Fortsetzung der Druck-Ausgabe"],"title":[{"title":"Clinical microbiology reviews","title_sort":"Clinical microbiology reviews"}]}],"person":[{"given":"Anna","family":"Dudakova","role":"aut","display":"Dudakova, Anna","roleDisplay":"VerfasserIn"},{"display":"Spiess, Birgit","roleDisplay":"VerfasserIn","role":"aut","family":"Spiess","given":"Birgit"},{"family":"Buchheidt","given":"Dieter","display":"Buchheidt, Dieter","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title_sort":"Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species","title":"Molecular tools for the detection and deduction of azole antifungal drug resistance phenotypes in Aspergillus species"}],"note":["Gesehen am 22.08.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1580301487"} | ||
| SRT | |a DUDAKOVAANMOLECULART1320 | ||