Parenchymal liver blood volume and dynamic volume perfusion CT measurements of hepatocellular carcinoma in patients undergoing transarterial chemoembolization
Aim: Prospective comparison of cone beam C-Arm CT based parenchymal liver blood volume (PLBV) and dynamic volume perfusion CT (dVPCT) measurements in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolisation (TACE) with drug-eluting beads (DEB). Patients and Methods: In...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 2017
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| In: |
Anticancer research
Year: 2017, Volume: 37, Issue: 10, Pages: 5681-5685 |
| ISSN: | 1791-7530 |
| Online Access: | Verlag, teilw. kostenfrei, Volltext: http://ar.iiarjournals.org/content/37/10/5681
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| Author Notes: | Nils Rathmann, Kerim Kara, Johannes Budjan, Thomas Henzler, Arman Smakic, Stefan O. Schoenberg and Steffen J. Diehl |
| Summary: | Aim: Prospective comparison of cone beam C-Arm CT based parenchymal liver blood volume (PLBV) and dynamic volume perfusion CT (dVPCT) measurements in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolisation (TACE) with drug-eluting beads (DEB). Patients and Methods: In 16 patients, changes of PLBV and dVPCT measurements [arterial liver parenchyma (ALP); temporal maximum intensity projection (MIP); hepatic perfusion index (HPI); portal venous parenchyma] were correlated to one another and to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Results: After TACE, the following parameters showed a statistically significant change (p<0.05) in mean value: PLBV: −4.85 ml/100 ml, ALP: −4.14 ml/100 ml/min, MIP: −0.23 Houndsfield units, HPI: −5.39%, and mRECIST: −20.53 mm. Pre-to-post TACE differences in PLBV showed only weak to very weak correlation to dVPCT parameters (r2<0.24). Conclusion: Although PLBV and dVPCT parameters showed only a weak to very weak correlation, both methods validly assessed changes in arterial tumor vascularity after DEB TACE. |
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| Item Description: | Gesehen am 16.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |