Buchumschlag

Angiogenesis and anti-angiogenic therapy in gastric cancer

Gastric cancer is one of the most frequent malignancies worldwide. Despite improvements in diagnosis and therapy, the overall prognosis remains poor. In the last decade, several anti-angiogenic drugs for cancer treatment have been approved and lately also introduced to gastric cancer treatment. Whil...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Nienhüser, Henrik (VerfasserIn) , Schmidt, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: International journal of molecular sciences
Year: 2018, Jahrgang: 19, Heft: 1
ISSN:1422-0067
DOI:10.3390/ijms19010043
Online-Zugang:Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.3390/ijms19010043
Verlag, kostenfrei, Volltext: http://www.mdpi.com/1422-0067/19/1/43
Volltext
Verfasserangaben:Henrik Nienhüser and Thomas Schmidt

MARC

LEADER 00000caa a2200000 c 4500
001 1580305652
003 DE-627
005 20250828162026.0
007 cr uuu---uuuuu
008 180822s2018 xx |||||o 00| ||eng c
024 7 |a 10.3390/ijms19010043  |2 doi 
035 |a (DE-627)1580305652 
035 |a (DE-576)510305652 
035 |a (DE-599)BSZ510305652 
035 |a (OCoLC)1341017458 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Nienhüser, Henrik  |d 1986-  |e VerfasserIn  |0 (DE-588)104690342X  |0 (DE-627)777295865  |0 (DE-576)398176477  |4 aut 
245 1 0 |a Angiogenesis and anti-angiogenic therapy in gastric cancer  |c Henrik Nienhüser and Thomas Schmidt 
264 1 |c 2018 
300 |a 17 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Published: 23 December 2017 
500 |a Gesehen am 22.08.2018 
520 |a Gastric cancer is one of the most frequent malignancies worldwide. Despite improvements in diagnosis and therapy, the overall prognosis remains poor. In the last decade, several anti-angiogenic drugs for cancer treatment have been approved and lately also introduced to gastric cancer treatment. While the initial trials focused only on unresectable or metastatic cancer, anti-angiogenic treatment is now also investigated in the perioperative and neoadjuvant setting. In this review, an overview of the role of angiogenesis and angiogenic factors in gastric cancer as well as anti-angiogenic treatment of gastric cancer is provided. Findings from in vitro and animal studies are summarized and put in a context with translational data on angiogenesis in gastric cancer. The most important angiogenic factors and their effect in gastric cancer are highlighted and clinical trials including anti-angiogenic drugs are discussed. Finally, an outlook of biomarkers for predicting response to anti-angiogenic treatment is presented, the ongoing trials on this topic are discussed and current challenges of anti-angiogenic therapy are outlined. 
650 4 |a angiogenesis 
650 4 |a gastric cancer 
650 4 |a perioperative chemotherapy 
650 4 |a vascular endothelial growth factor 
700 1 |a Schmidt, Thomas  |d 1980-  |e VerfasserIn  |0 (DE-588)132383152  |0 (DE-627)521950023  |0 (DE-576)260799149  |4 aut 
773 0 8 |i Enthalten in  |t International journal of molecular sciences  |d Basel : Molecular Diversity Preservation International, 2000  |g 19(2018,1) Artikel-Nummer 43, 17 Seiten  |h Online-Ressource  |w (DE-627)316340715  |w (DE-600)2019364-6  |w (DE-576)281194653  |x 1422-0067  |7 nnas  |a Angiogenesis and anti-angiogenic therapy in gastric cancer 
773 1 8 |g volume:19  |g year:2018  |g number:1  |g extent:17  |a Angiogenesis and anti-angiogenic therapy in gastric cancer 
856 4 0 |u http://dx.doi.org/10.3390/ijms19010043  |x Resolving-System  |x Verlag  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.mdpi.com/1422-0067/19/1/43  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20180822 
993 |a Article 
994 |a 2018 
998 |g 132383152  |a Schmidt, Thomas  |m 132383152:Schmidt, Thomas  |d 910000  |d 910200  |d 50000  |e 910000PS132383152  |e 910200PS132383152  |e 50000PS132383152  |k 0/910000/  |k 1/910000/910200/  |k 0/50000/  |p 2  |y j 
998 |g 104690342X  |a Nienhüser, Henrik  |m 104690342X:Nienhüser, Henrik  |d 910000  |d 910200  |e 910000PN104690342X  |e 910200PN104690342X  |k 0/910000/  |k 1/910000/910200/  |p 1  |x j 
999 |a KXP-PPN1580305652  |e 302297423X 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Published: 23 December 2017","Gesehen am 22.08.2018"],"title":[{"title":"Angiogenesis and anti-angiogenic therapy in gastric cancer","title_sort":"Angiogenesis and anti-angiogenic therapy in gastric cancer"}],"person":[{"display":"Nienhüser, Henrik","given":"Henrik","family":"Nienhüser","role":"aut"},{"role":"aut","family":"Schmidt","given":"Thomas","display":"Schmidt, Thomas"}],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"17 S."}],"language":["eng"],"id":{"eki":["1580305652"],"doi":["10.3390/ijms19010043"]},"recId":"1580305652","name":{"displayForm":["Henrik Nienhüser and Thomas Schmidt"]},"relHost":[{"title":[{"title_sort":"International journal of molecular sciences","title":"International journal of molecular sciences"}],"pubHistory":["1.2000 -"],"origin":[{"dateIssuedKey":"2000","publisher":"Molecular Diversity Preservation International","dateIssuedDisp":"2000-","publisherPlace":"Basel"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 17.09.20"],"id":{"eki":["316340715"],"issn":["1422-0067","1661-6596"],"zdb":["2019364-6"]},"recId":"316340715","titleAlt":[{"title":"IJMS"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Angiogenesis and anti-angiogenic therapy in gastric cancerInternational journal of molecular sciences","part":{"volume":"19","extent":"17","year":"2018","issue":"1","text":"19(2018,1) Artikel-Nummer 43, 17 Seiten"},"language":["eng"]}]} 
SRT |a NIENHUESERANGIOGENES2018 

Ähnliche Einträge