Liquid biopsy: value for melanoma therapy?
Treatment of metastatic melanoma has undergone tremendous changes over the past few years. There are now highly effective systemic therapies available: targeted therapy with BRAF and MEK inhibitors in BRAF-V600-mutant melanoma and immunotherapies, including PD-1 antibodies with or without CTLA-4 ant...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 19, 2017
|
| In: |
Oncology research and treatment
Year: 2017, Jahrgang: 40, Heft: 7/8, Pages: 430-434 |
| ISSN: | 2296-5262 |
| DOI: | 10.1159/000478893 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1159/000478893
|
| Verfasserangaben: | Kristina Buder-Bakhaya, Devayani Machiraju, Jessica C. Hassel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580306640 | ||
| 003 | DE-627 | ||
| 005 | 20251027103144.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180822s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000478893 |2 doi | |
| 035 | |a (DE-627)1580306640 | ||
| 035 | |a (DE-576)510306640 | ||
| 035 | |a (DE-599)BSZ510306640 | ||
| 035 | |a (OCoLC)1341017343 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Buder-Bakhaya, Kristina |e VerfasserIn |0 (DE-588)1162458259 |0 (DE-627)1026055989 |0 (DE-576)507404831 |4 aut | |
| 245 | 1 | 0 | |a Liquid biopsy |b value for melanoma therapy? |c Kristina Buder-Bakhaya, Devayani Machiraju, Jessica C. Hassel |
| 264 | 1 | |c July 19, 2017 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.08.2018 | ||
| 520 | |a Treatment of metastatic melanoma has undergone tremendous changes over the past few years. There are now highly effective systemic therapies available: targeted therapy with BRAF and MEK inhibitors in BRAF-V600-mutant melanoma and immunotherapies, including PD-1 antibodies with or without CTLA-4 antibody, that can be used regardless of mutational status. However, long-term tumor control is only achieved in a minority of patients. Liquid biopsy using circulating tumor cells, circulating tumor DNA (ctDNA), circulating mRNA and micro-RNA might represent valuable biomarkers, e.g. in the setting of systemic treatment for metastatic melanoma. Pre-treatment detection of BRAF V600-mutant ctDNA has been shown to be a prognostic factor in patients receiving BRAF/MEK inhibitor treatment. Furthermore, monitoring of ctDNA of known driver mutations can be used for treatment monitoring and detection of acquired resistance. However, results of the currently available studies need to be interpreted with caution as multiple approaches were used that are hardly comparable. So far, even with advancement of methods, there are only prognostic but no predictive biomarkers available. | ||
| 700 | 1 | |a Machiraju, Devayani |e VerfasserIn |0 (DE-588)1165195224 |0 (DE-627)1029355924 |0 (DE-576)510306586 |4 aut | |
| 700 | 1 | |a Hassel, Jessica C. |d 1975- |e VerfasserIn |0 (DE-588)129790702 |0 (DE-627)480399069 |0 (DE-576)29783715X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncology research and treatment |d Basel : Karger, 2014 |g 40(2017), 7/8, Seite 430-434 |h Online-Ressource |w (DE-627)776629611 |w (DE-600)2749752-5 |w (DE-576)400081660 |x 2296-5262 |7 nnas |a Liquid biopsy value for melanoma therapy? |
| 773 | 1 | 8 | |g volume:40 |g year:2017 |g number:7/8 |g pages:430-434 |g extent:5 |a Liquid biopsy value for melanoma therapy? |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000478893 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180822 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 129790702 |a Hassel, Jessica C. |m 129790702:Hassel, Jessica C. |d 910000 |d 911300 |e 910000PH129790702 |e 911300PH129790702 |k 0/910000/ |k 1/910000/911300/ |p 3 |y j | ||
| 998 | |g 1165195224 |a Machiraju, Devayani |m 1165195224:Machiraju, Devayani |d 910000 |e 910000PM1165195224 |k 0/910000/ |p 2 | ||
| 998 | |g 1162458259 |a Buder-Bakhaya, Kristina |m 1162458259:Buder-Bakhaya, Kristina |d 910000 |e 910000PB1162458259 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580306640 |e 3022975309 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Kristina Buder-Bakhaya, Devayani Machiraju, Jessica C. Hassel"]},"id":{"eki":["1580306640"],"doi":["10.1159/000478893"]},"physDesc":[{"extent":"5 S."}],"recId":"1580306640","person":[{"display":"Buder-Bakhaya, Kristina","family":"Buder-Bakhaya","role":"aut","given":"Kristina"},{"display":"Machiraju, Devayani","family":"Machiraju","role":"aut","given":"Devayani"},{"family":"Hassel","role":"aut","given":"Jessica C.","display":"Hassel, Jessica C."}],"relHost":[{"part":{"extent":"5","text":"40(2017), 7/8, Seite 430-434","issue":"7/8","pages":"430-434","volume":"40","year":"2017"},"title":[{"title":"Oncology research and treatment","title_sort":"Oncology research and treatment"}],"id":{"issn":["2296-5262"],"eki":["776629611"],"zdb":["2749752-5"]},"note":["Gesehen am 15.12.2023"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["37.2014 -"],"origin":[{"publisher":"Karger","dateIssuedDisp":"2014-","dateIssuedKey":"2014","publisherPlace":"Basel"}],"disp":"Liquid biopsy value for melanoma therapy?Oncology research and treatment","recId":"776629611","physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"July 19, 2017"}],"note":["Gesehen am 22.08.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title":"Liquid biopsy","title_sort":"Liquid biopsy","subtitle":"value for melanoma therapy?"}]} | ||
| SRT | |a BUDERBAKHALIQUIDBIOP1920 | ||