The spider effect: morphological and orienting classification of microglia in response to stimuli in vivo
The different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: f...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 21, 2012
|
| In: |
PLOS ONE
Year: 2012, Jahrgang: 7, Heft: 2 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0030763 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0030763 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030763 
|
| Verfasserangaben: | Rahul A. Jonas, Ti-Fei Yuan, Yu-Xiang Liang, Jost B. Jonas, David K. C. Tay, Rutledge G. Ellis-Behnke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580308023 | ||
| 003 | DE-627 | ||
| 005 | 20220814230941.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180822s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0030763 |2 doi | |
| 035 | |a (DE-627)1580308023 | ||
| 035 | |a (DE-576)510308023 | ||
| 035 | |a (DE-599)BSZ510308023 | ||
| 035 | |a (OCoLC)1341017403 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jonas, Rahul A. |e VerfasserIn |0 (DE-588)1149188863 |0 (DE-627)1009503022 |0 (DE-576)496597035 |4 aut | |
| 245 | 1 | 4 | |a The spider effect |b morphological and orienting classification of microglia in response to stimuli in vivo |c Rahul A. Jonas, Ti-Fei Yuan, Yu-Xiang Liang, Jost B. Jonas, David K. C. Tay, Rutledge G. Ellis-Behnke |
| 264 | 1 | |c February 21, 2012 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.208.2018 | ||
| 520 | |a The different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased, the cell process number decreased, and the cell processes retracted and thickened, orienting toward the direction of the injury site; until stage 6A, when all processes disappeared. In contrast, in deactivation stages 6R to 1R, the microglia returned to the original site exhibiting a stepwise retransformation to the original morphology. Thin highly branched processes re-formed in stage 1R, similar to those in stage 1A. This reverse transformation mirrored the forward transformation except in stages 6R to 1R: cells showed multiple nuclei which were slowly absorbed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. | ||
| 650 | 4 | |a Cell processes | |
| 650 | 4 | |a Cell staining | |
| 650 | 4 | |a Central nervous system | |
| 650 | 4 | |a Histology | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a Microglial cells | |
| 650 | 4 | |a Olfactory bulb | |
| 650 | 4 | |a Spider webs | |
| 700 | 1 | |a Jonas, Jost B. |d 1958- |e VerfasserIn |0 (DE-588)1028286732 |0 (DE-627)730536823 |0 (DE-576)37578537X |4 aut | |
| 700 | 1 | |a Ellis-Behnke, Rutledge |e VerfasserIn |0 (DE-588)1156309182 |0 (DE-627)1018859950 |0 (DE-576)426349830 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 7(2012,2) Artikel-Nummer e30763, 12 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a The spider effect morphological and orienting classification of microglia in response to stimuli in vivo |
| 773 | 1 | 8 | |g volume:7 |g year:2012 |g number:2 |g extent:12 |a The spider effect morphological and orienting classification of microglia in response to stimuli in vivo |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0030763 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030763 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180822 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1156309182 |a Ellis-Behnke, Rutledge |m 1156309182:Ellis-Behnke, Rutledge |d 60000 |d 61700 |e 60000PE1156309182 |e 61700PE1156309182 |k 0/60000/ |k 1/60000/61700/ |p 6 |y j | ||
| 998 | |g 1028286732 |a Jonas, Jost B. |m 1028286732:Jonas, Jost B. |d 60000 |d 61700 |e 60000PJ1028286732 |e 61700PJ1028286732 |k 0/60000/ |k 1/60000/61700/ |p 4 | ||
| 998 | |g 1149188863 |a Jonas, Rahul A. |m 1149188863:Jonas, Rahul A. |d 60000 |d 61700 |e 60000PJ1149188863 |e 61700PJ1149188863 |k 0/60000/ |k 1/60000/61700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580308023 |e 302297650X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 22.208.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"part":{"text":"7(2012,2) Artikel-Nummer e30763, 12 Seiten","year":"2012","volume":"7","issue":"2","extent":"12"},"origin":[{"publisher":"PLOS ; PLoS","publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","dateIssuedKey":"2006","dateIssuedDisp":"2006-"}],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"language":["eng"],"recId":"523574592","title":[{"title_sort":"PLOS ONE","title":"PLOS ONE"}],"name":{"displayForm":["Public Library of Science"]},"pubHistory":["1.2006 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2267670-3"],"eki":["523574592"],"issn":["1932-6203"]},"disp":"The spider effect morphological and orienting classification of microglia in response to stimuli in vivoPLOS ONE","corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"Public Library of Science"}]}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"February 21, 2012"}],"recId":"1580308023","id":{"eki":["1580308023"],"doi":["10.1371/journal.pone.0030763"]},"language":["eng"],"physDesc":[{"extent":"12 S."}],"title":[{"title":"The spider effect","subtitle":"morphological and orienting classification of microglia in response to stimuli in vivo","title_sort":"spider effect"}],"person":[{"display":"Jonas, Rahul A.","given":"Rahul A.","family":"Jonas","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Jonas","given":"Jost B.","display":"Jonas, Jost B."},{"family":"Ellis-Behnke","role":"aut","roleDisplay":"VerfasserIn","given":"Rutledge","display":"Ellis-Behnke, Rutledge"}],"name":{"displayForm":["Rahul A. Jonas, Ti-Fei Yuan, Yu-Xiang Liang, Jost B. Jonas, David K. C. Tay, Rutledge G. Ellis-Behnke"]}} | ||
| SRT | |a JONASRAHULSPIDEREFFE2120 | ||