Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins
Frankenstein′s peptide: The grafting of the binding domain from miniprotein Min-23 into the sunflower trypsin inhibitor (SFTI-I) peptide scaffold (see scheme) preserved its in vitro and in vivo binding specificity and proteolytic stability. The combination of these peptides was shown to be tumor-spe...
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| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 13, 2012
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| In: |
Angewandte Chemie. International edition
Year: 2012, Jahrgang: 51, Heft: 52, Pages: 13136-13139 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201203857 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/anie.201203857 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201203857 
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| Verfasserangaben: | Frederic Zoller, Annette Markert, Philippe Barthe, Wenye Zhao, Wilko Weichert, Vasileios Askoxylakis, Annette Altmann, Walter Mier, and Uwe Haberkorn |
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