Intestinal stem cell function in Drosophila and mice
Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis....
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19th May 2012
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| In: |
Current opinion in genetics & development
Year: 2012, Jahrgang: 22, Heft: 4, Pages: 354-360 |
| ISSN: | 1879-0380 |
| DOI: | 10.1016/j.gde.2012.04.002 |
| Online-Zugang: | Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0959437X12000469 Verlag, Volltext: http://dx.doi.org/10.1016/j.gde.2012.04.002 
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| Verfasserangaben: | Huaqi Jiang and Bruce A Edgar |
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| 520 | |a Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation. | ||
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