Predictors of survival stratification in patients with wild-type cardiac amyloidosis
ObjectivesTo analyze clinical predictors of mortality in wild-type transthyretin amyloidosis (wt-ATTR).MethodsIn total, 191 patients (73.8 ± 0.5 years; 176 males, 15 females) with histologically proven wt-ATTR amyloidosis and genetic exclusion of a transthyretin gene variant were included. Comprehen...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
|
| In: |
Clinical research in cardiology
Year: 2018, Jahrgang: 107, Heft: 2, Pages: 158-169 |
| ISSN: | 1861-0692 |
| DOI: | 10.1007/s00392-017-1167-1 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00392-017-1167-1 Verlag, Volltext: https://doi.org/10.1007/s00392-017-1167-1 
|
| Verfasserangaben: | F. aus dem Siepen, R. Bauer, A. Voss, S. Hein, M. Aurich, J. Riffel, D. Mereles, C. Röcken, S.J. Buss, H.A. Katus, Arnt V. Kristen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580401090 | ||
| 003 | DE-627 | ||
| 005 | 20251030141703.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180827s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00392-017-1167-1 |2 doi | |
| 035 | |a (DE-627)1580401090 | ||
| 035 | |a (DE-576)510401090 | ||
| 035 | |a (DE-599)BSZ510401090 | ||
| 035 | |a (OCoLC)1341017448 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Siepen, Fabian aus dem |d 1984- |e VerfasserIn |0 (DE-588)1066499969 |0 (DE-627)817646469 |0 (DE-576)426014944 |4 aut | |
| 245 | 1 | 0 | |a Predictors of survival stratification in patients with wild-type cardiac amyloidosis |c F. aus dem Siepen, R. Bauer, A. Voss, S. Hein, M. Aurich, J. Riffel, D. Mereles, C. Röcken, S.J. Buss, H.A. Katus, Arnt V. Kristen |
| 264 | 1 | |c 2018 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 27 September 2017 | ||
| 500 | |a Gesehen am 27.08.2018 | ||
| 520 | |a ObjectivesTo analyze clinical predictors of mortality in wild-type transthyretin amyloidosis (wt-ATTR).MethodsIn total, 191 patients (73.8 ± 0.5 years; 176 males, 15 females) with histologically proven wt-ATTR amyloidosis and genetic exclusion of a transthyretin gene variant were included. Comprehensive clinical characteristics, ECG, biomarkers, and echocardiography were analyzed retrospectively. Strain analyses were performed offline using TomTec Imaging Systems, Germany. Univariable and multivariable analyses predicting all-cause mortality were carried out.ResultsPatients presented with significant heart failure (NYHA 2.5 ± 0.8; NT-proBNP 3644 (4981) pg/ml; LV ejection fraction 45.8 ± 15.0%). LogNT-proBNP correlated with indicators of disease severity. Similar results were obtained for basal and midventricular, but not apical longitudinal strain. During median follow-up of 26.2 ± 1.7 months 46 (25.5%) patients died (40 males, 23%; six females, 40%). In female patients 1-/2-year survival was lower [92.9/67.7%; median survival 30.6 (21.1-40.1) months] when compared to male patients [96.5%/86.6%; median survival 63.9 (45.8-82.0) months]. Parameters associated with survival were NT-proBNP, NYHA class, heart rate, midventricular longitudinal strain, mitral annular plane systolic excursion (MAPSE), Karnofsky Index, systolic blood pressure, estimated glomerular filtration rate. Multivariable analysis revealed MAPSE and NT-proBNP as independent predictors of mortality in the whole cohort and midventricular strain in the subgroup of patients in sinus rhythm.ConclusionsNo sex-specific bias was observed between male and female patients with wt-ATTR regarding age at onset and morphological characteristics. Multivariable analysis revealed MAPSE and NT-proBNP as independent predictors of survival in the whole cohort, whereas midventricular longitudinal strain was the only independent predictor in patients in sinus rhythm. | ||
| 650 | 4 | |a Amyloidosis | |
| 650 | 4 | |a Sex differences | |
| 650 | 4 | |a Strain rate imaging | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Transthyretin | |
| 700 | 1 | |a Bauer, Ralf |e VerfasserIn |0 (DE-588)1056026111 |0 (DE-627)793159849 |0 (DE-576)412038293 |4 aut | |
| 700 | 1 | |a Voß, Andreas |d 1972- |e VerfasserIn |0 (DE-588)1028372574 |0 (DE-627)730618919 |0 (DE-576)375905065 |4 aut | |
| 700 | 1 | |a Hein, Selina |d 1985- |e VerfasserIn |0 (DE-588)1045012297 |0 (DE-627)773397035 |0 (DE-576)398324395 |4 aut | |
| 700 | 1 | |a Aurich, Matthias |d 1983- |e VerfasserIn |0 (DE-588)1059231417 |0 (DE-627)798165715 |0 (DE-576)415235421 |4 aut | |
| 700 | 1 | |a Riffel, Johannes |d 1981- |e VerfasserIn |0 (DE-588)1034182676 |0 (DE-627)744891809 |0 (DE-576)381796078 |4 aut | |
| 700 | 1 | |a Mereles, Derliz |d 1963- |e VerfasserIn |0 (DE-588)129031062 |0 (DE-627)387883754 |0 (DE-576)297456970 |4 aut | |
| 700 | 1 | |a Buß, Sebastian Johannes |d 1977- |e VerfasserIn |0 (DE-588)131490451 |0 (DE-627)509814050 |0 (DE-576)298541963 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Kristen, Arnt |d 1974- |e VerfasserIn |0 (DE-588)123480965 |0 (DE-627)706314530 |0 (DE-576)293726876 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical research in cardiology |d Berlin : Springer, 2006 |g 107(2018), 2, Seite 158-169 |h Online-Ressource |w (DE-627)506287343 |w (DE-600)2218331-0 |w (DE-576)251097692 |x 1861-0692 |7 nnas |a Predictors of survival stratification in patients with wild-type cardiac amyloidosis |
| 773 | 1 | 8 | |g volume:107 |g year:2018 |g number:2 |g pages:158-169 |g extent:12 |a Predictors of survival stratification in patients with wild-type cardiac amyloidosis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00392-017-1167-1 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00392-017-1167-1 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180827 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 123480965 |a Kristen, Arnt |m 123480965:Kristen, Arnt |d 910000 |d 910100 |e 910000PK123480965 |e 910100PK123480965 |k 0/910000/ |k 1/910000/910100/ |p 11 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 131490451 |a Buß, Sebastian Johannes |m 131490451:Buß, Sebastian Johannes |d 50000 |e 50000PB131490451 |k 0/50000/ |p 9 | ||
| 998 | |g 129031062 |a Mereles, Derliz |m 129031062:Mereles, Derliz |d 910000 |d 910100 |e 910000PM129031062 |e 910100PM129031062 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1034182676 |a Riffel, Johannes |m 1034182676:Riffel, Johannes |d 910000 |d 910100 |e 910000PR1034182676 |e 910100PR1034182676 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1059231417 |a Aurich, Matthias |m 1059231417:Aurich, Matthias |d 910000 |d 910100 |e 910000PA1059231417 |e 910100PA1059231417 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1045012297 |a Hein, Selina |m 1045012297:Hein, Selina |d 910000 |d 910100 |e 910000PH1045012297 |e 910100PH1045012297 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1028372574 |a Voß, Andreas |m 1028372574:Voß, Andreas |d 910000 |d 910700 |e 910000PV1028372574 |e 910700PV1028372574 |k 0/910000/ |k 1/910000/910700/ |p 3 | ||
| 998 | |g 1056026111 |a Bauer, Ralf |m 1056026111:Bauer, Ralf |d 910000 |d 910100 |e 910000PB1056026111 |e 910100PB1056026111 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1066499969 |a Siepen, Fabian aus dem |m 1066499969:Siepen, Fabian aus dem |d 910000 |d 910100 |e 910000PS1066499969 |e 910100PS1066499969 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580401090 |e 3023863563 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1007/s00392-017-1167-1"],"eki":["1580401090"]},"name":{"displayForm":["F. aus dem Siepen, R. Bauer, A. Voss, S. Hein, M. Aurich, J. Riffel, D. Mereles, C. Röcken, S.J. Buss, H.A. Katus, Arnt V. Kristen"]},"recId":"1580401090","physDesc":[{"extent":"12 S."}],"title":[{"title_sort":"Predictors of survival stratification in patients with wild-type cardiac amyloidosis","title":"Predictors of survival stratification in patients with wild-type cardiac amyloidosis"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published online: 27 September 2017","Gesehen am 27.08.2018"],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"relHost":[{"recId":"506287343","physDesc":[{"extent":"Online-Ressource"}],"disp":"Predictors of survival stratification in patients with wild-type cardiac amyloidosisClinical research in cardiology","pubHistory":["95.2006 -"],"origin":[{"publisher":"Springer","dateIssuedKey":"2006","publisherPlace":"Berlin","dateIssuedDisp":"2006-"}],"title":[{"title_sort":"Clinical research in cardiology","title":"Clinical research in cardiology"}],"part":{"year":"2018","volume":"107","pages":"158-169","text":"107(2018), 2, Seite 158-169","extent":"12","issue":"2"},"id":{"eki":["506287343"],"issn":["1861-0692"],"zdb":["2218331-0"]},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"person":[{"given":"Fabian aus dem","role":"aut","family":"Siepen","display":"Siepen, Fabian aus dem"},{"given":"Ralf","role":"aut","family":"Bauer","display":"Bauer, Ralf"},{"display":"Voß, Andreas","given":"Andreas","role":"aut","family":"Voß"},{"given":"Selina","role":"aut","family":"Hein","display":"Hein, Selina"},{"family":"Aurich","given":"Matthias","role":"aut","display":"Aurich, Matthias"},{"display":"Riffel, Johannes","role":"aut","given":"Johannes","family":"Riffel"},{"display":"Mereles, Derliz","family":"Mereles","role":"aut","given":"Derliz"},{"display":"Buß, Sebastian Johannes","role":"aut","given":"Sebastian Johannes","family":"Buß"},{"display":"Katus, Hugo","family":"Katus","given":"Hugo","role":"aut"},{"display":"Kristen, Arnt","family":"Kristen","given":"Arnt","role":"aut"}]} | ||
| SRT | |a SIEPENFABIPREDICTORS2018 | ||