Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia

<p>Members of the histone deacetylase (HDAC) family exhibit great promise as potential drug targets in pediatric tumors including neuroblastoma, medulloblastoma, ependymoma and Ewing’s sarcoma. HDAC inhibitors of various structural classes have shown anti-tumoral effects in pre-clinical pediat...

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Main Authors: Witt, Olaf (Author) , Milde, Till (Author) , Deubzer, Hedwig (Author) , Oehme, Ina (Author) , Kulozik, Andreas (Author) , Eisenmenger, Andreas (Author) , Abel, Ulrich (Author) , Karapanagiotou-Schenkel, Irini (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Klinische Pädiatrie
Year: 2012, Volume: 224, Issue: 06, Pages: 398-403
ISSN:1439-3824
DOI:10.1055/s-0032-1323692
Online Access:Verlag, Volltext: http://dx.doi.org/10.1055/s-0032-1323692
Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1323692
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Author Notes:O. Witt, T. Milde, H.E. Deubzer, I. Oehme, R. Witt, A. Kulozik, A. Eisenmenger, U. Abel, I. Karapanagiotou-Schenkel
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Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia by Tilburg, Cornelis M. van (Author) , Milde, Till (Author) , Witt, Ruth (Author) , Ecker, Jonas (Author) , Hielscher, Thomas (Author) , Seitz, Angelika (Author) , Schenk, Jens-Peter (Author) , Buhl, Juliane (Author) , Riehl, Dennis (Author) , Frühwald, Michael (Author) , Pekrun, Arnulf (Author) , Rössig, Claudia (Author) , Wieland, Regina Paula Franziska (Author) , Flotho, Christian (Author) , Kordes, Uwe (Author) , Gruhn, Bernd (Author) , Simon, Thorsten (Author) , Linderkamp, Christin (Author) , Sahm, Felix (Author) , Taylor, Lenka A. (Author) , Freitag, Angelika (Author) , Burhenne, Jürgen (Author) , Foerster, Kathrin (Author) , Meid, Andreas (Author) , Pfister, Stefan (Author) , Karapanagiotou-Schenkel, Irini (Author) , Witt, Olaf (Author) ,


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