Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia
<p>Members of the histone deacetylase (HDAC) family exhibit great promise as potential drug targets in pediatric tumors including neuroblastoma, medulloblastoma, ependymoma and Ewing’s sarcoma. HDAC inhibitors of various structural classes have shown anti-tumoral effects in pre-clinical pediat...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
|
| In: |
Klinische Pädiatrie
Year: 2012, Volume: 224, Issue: 06, Pages: 398-403 |
| ISSN: | 1439-3824 |
| DOI: | 10.1055/s-0032-1323692 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1055/s-0032-1323692 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1323692 |
| Author Notes: | O. Witt, T. Milde, H.E. Deubzer, I. Oehme, R. Witt, A. Kulozik, A. Eisenmenger, U. Abel, I. Karapanagiotou-Schenkel |
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