Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids
Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA2β is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA2...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 September 2017
|
| In: |
Biochimica et biophysica acta
Year: 2017, Jahrgang: 1862, Heft: 12, Pages: 1520-1533 |
| ISSN: | 1878-2434 |
| DOI: | 10.1016/j.bbalip.2017.09.001 |
| Online-Zugang: | Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1388198117301865 Verlag, Volltext: http://dx.doi.org/10.1016/j.bbalip.2017.09.001 
|
| Verfasserangaben: | Li Jiao, Hongying Gan-Schreier, Xingya Zhu, Wang Wei, Sabine Tuma-Kellner, Gerhard Liebisch, Wolfgang Stremmel, Walee Chamulitrat |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580437559 | ||
| 003 | DE-627 | ||
| 005 | 20230427065659.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180828s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bbalip.2017.09.001 |2 doi | |
| 035 | |a (DE-627)1580437559 | ||
| 035 | |a (DE-576)510437559 | ||
| 035 | |a (DE-599)BSZ510437559 | ||
| 035 | |a (OCoLC)1341017624 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jiao, Li |e VerfasserIn |0 (DE-588)1110067860 |0 (DE-627)864777914 |0 (DE-576)475712900 |4 aut | |
| 245 | 1 | 0 | |a Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids |c Li Jiao, Hongying Gan-Schreier, Xingya Zhu, Wang Wei, Sabine Tuma-Kellner, Gerhard Liebisch, Wolfgang Stremmel, Walee Chamulitrat |
| 264 | 1 | |c 06 September 2017 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 06 September 2017 | ||
| 500 | |a Gesehen am 28.08.2018 | ||
| 520 | |a Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA2β is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA2β−/− mice exhibit aged-dependent phenotypes with body weight loss and abnormalities in the bone and brain. We have previously reported the abnormalities in these mutant mice showing susceptibility for chemical-induced liver injury and colitis. We hypothesize that iPLA2β deficiency may sensitize with ageing for an induction of GI injury. Male wild-type and iPLA2β−/− mice at 4 and 20-22months of age were studied. Aged, but not young, iPLA2β−/−mice showed increased hepatic fibrosis and biliary ductular expansion as well as severe intestinal atrophy associated with increased apoptosis, pro-inflammation, disrupted tight junction, and reduced number of mucin-containing globlet cells. This damage was associated with decreased expression of intestinal endoplasmic stress XBP1 and its regulator HNF1α, FATP4, ACSL5, bile-acid transport genes as well as nuclear receptors LXRα and FXR. By LC/MS-MS profiling, iPLA2β deficiency in aged mice caused an increase of intestinal arachidonate-containing phospholipids concomitant with a decrease in ceramides. By the suppression of intestinal FXR/FGF-15 signaling, hepatic bile-acid synthesis gene expression was increased leading to an elevation of secondary and hydrophobic bile acids in liver, bile, and intestine. In conclusions, ageing sensitized by iPLA2β deficiency caused a decline of key intestinal homeostatic genes resulting in the development of GI disease in a gut-to-liver manner. | ||
| 650 | 4 | |a Ageing | |
| 650 | 4 | |a FXR | |
| 650 | 4 | |a Intestinal homeostasis | |
| 650 | 4 | |a Lipidomics | |
| 650 | 4 | |a Pla2G6 | |
| 650 | 4 | |a XBP1 | |
| 700 | 1 | |a Gan-Schreier, Hongying |d 1967- |e VerfasserIn |0 (DE-588)130102040 |0 (DE-627)490859860 |0 (DE-576)297997955 |4 aut | |
| 700 | 1 | |a Zhu, Xingya |d 1990- |e VerfasserIn |0 (DE-588)1165586487 |0 (DE-627)1029648123 |0 (DE-576)51043696X |4 aut | |
| 700 | 1 | |a Wei, Wang |d 1985- |e VerfasserIn |0 (DE-588)1094885118 |0 (DE-627)855358300 |0 (DE-576)462842827 |4 aut | |
| 700 | 1 | |a Tuma-Kellner, Sabine |e VerfasserIn |0 (DE-588)111098653X |0 (DE-627)865272743 |0 (DE-576)475865979 |4 aut | |
| 700 | 1 | |a Stremmel, Wolfgang |d 1952- |e VerfasserIn |0 (DE-588)142773638 |0 (DE-627)640118747 |0 (DE-576)33331560X |4 aut | |
| 700 | 1 | |a Chamulitrat, Walee |d 1959- |e VerfasserIn |0 (DE-588)1037336828 |0 (DE-627)755493915 |0 (DE-576)39134479X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochimica et biophysica acta |d Amsterdam [u.a.] : Elsevier, 1947 |g 1862(2017), 12, Seite 1520-1533 |h Online-Ressource |w (DE-627)253779626 |w (DE-600)1460387-1 |w (DE-576)072793821 |x 1878-2434 |7 nnas |a Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids |
| 773 | 1 | 8 | |g volume:1862 |g year:2017 |g number:12 |g pages:1520-1533 |g extent:14 |a Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1388198117301865 |x Verlag |3 Volltext |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bbalip.2017.09.001 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180828 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1037336828 |a Chamulitrat, Walee |m 1037336828:Chamulitrat, Walee |d 910000 |d 910100 |e 910000PC1037336828 |e 910100PC1037336828 |k 0/910000/ |k 1/910000/910100/ |p 8 |y j | ||
| 998 | |g 142773638 |a Stremmel, Wolfgang |m 142773638:Stremmel, Wolfgang |d 910000 |d 910100 |e 910000PS142773638 |e 910100PS142773638 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 111098653X |a Tuma-Kellner, Sabine |m 111098653X:Tuma-Kellner, Sabine |p 5 | ||
| 998 | |g 1094885118 |a Wei, Wang |m 1094885118:Wei, Wang |d 910000 |e 910000PW1094885118 |k 0/910000/ |p 4 | ||
| 998 | |g 1165586487 |a Zhu, Xingya |m 1165586487:Zhu, Xingya |d 910000 |d 910100 |e 910000PZ1165586487 |e 910100PZ1165586487 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 130102040 |a Gan-Schreier, Hongying |m 130102040:Gan-Schreier, Hongying |d 910000 |d 910100 |e 910000PG130102040 |e 910100PG130102040 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1110067860 |a Jiao, Li |m 1110067860:Jiao, Li |d 910000 |d 910100 |e 910000PJ1110067860 |e 910100PJ1110067860 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580437559 |e 3024032185 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids","title_sort":"Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids"}],"person":[{"family":"Jiao","given":"Li","roleDisplay":"VerfasserIn","display":"Jiao, Li","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Gan-Schreier, Hongying","role":"aut","family":"Gan-Schreier","given":"Hongying"},{"role":"aut","display":"Zhu, Xingya","roleDisplay":"VerfasserIn","given":"Xingya","family":"Zhu"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wei, Wang","given":"Wang","family":"Wei"},{"given":"Sabine","family":"Tuma-Kellner","role":"aut","display":"Tuma-Kellner, Sabine","roleDisplay":"VerfasserIn"},{"given":"Wolfgang","family":"Stremmel","role":"aut","roleDisplay":"VerfasserIn","display":"Stremmel, Wolfgang"},{"roleDisplay":"VerfasserIn","display":"Chamulitrat, Walee","role":"aut","family":"Chamulitrat","given":"Walee"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Available online 06 September 2017","Gesehen am 28.08.2018"],"language":["eng"],"recId":"1580437559","origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"06 September 2017"}],"id":{"doi":["10.1016/j.bbalip.2017.09.001"],"eki":["1580437559"]},"name":{"displayForm":["Li Jiao, Hongying Gan-Schreier, Xingya Zhu, Wang Wei, Sabine Tuma-Kellner, Gerhard Liebisch, Wolfgang Stremmel, Walee Chamulitrat"]},"physDesc":[{"extent":"14 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["ed. board W. T. Astbury [u.a.]"]},"origin":[{"dateIssuedDisp":"1947-2016","dateIssuedKey":"1947","publisher":"Elsevier","publisherPlace":"Amsterdam [u.a.]"}],"id":{"zdb":["1460387-1"],"eki":["253779626"],"issn":["1878-2434"]},"disp":"Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acidsBiochimica et biophysica acta","note":["Gesehen am 14.10.2020","Bis 2016 einzelne Bände zugleich Bände der Sektionen"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"253779626","language":["eng"],"pubHistory":["1.1947 - 1826.2012; Vol. 1827.2013 - 1866.2016"],"part":{"pages":"1520-1533","issue":"12","year":"2017","extent":"14","text":"1862(2017), 12, Seite 1520-1533","volume":"1862"},"titleAlt":[{"title":"BBA"}],"title":[{"title":"Biochimica et biophysica acta","subtitle":"BBA ; international journal of biochemistry, biophysics and molecular biology","title_sort":"Biochimica et biophysica acta"}]}]} | ||
| SRT | |a JIAOLIGANSAGEINGSENS0620 | ||