Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer
The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2) and uses Salmonella typhi Ty21a as a vector. The immune reaction elicited by VXM01 is expected to disrupt the tumor neovasculature and, consequently, inhibit tumor growth. VXM01 potentially...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 August 2012
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| In: |
BMC cancer
Year: 2012, Jahrgang: 12 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-12-361 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2407-12-361 Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-361 
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| Verfasserangaben: | Andreas G. Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W. Buchler, Moritz Koch, Jürgen Weitz, Walter E. Haefeli and Friedrich H. Schmitz-Winnenthal |
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| 245 | 1 | 0 | |a Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer |c Andreas G. Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W. Buchler, Moritz Koch, Jürgen Weitz, Walter E. Haefeli and Friedrich H. Schmitz-Winnenthal |
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| 520 | |a The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2) and uses Salmonella typhi Ty21a as a vector. The immune reaction elicited by VXM01 is expected to disrupt the tumor neovasculature and, consequently, inhibit tumor growth. VXM01 potentially combines the advantages of anti-angiogenic therapy and active immunotherapy. | ||
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