The giant protein titin regulates the length of the striated muscle thick filament
Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 October 2017
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| In: |
Nature Communications
Year: 2017, Jahrgang: 8 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01144-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01144-9
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| Verfasserangaben: | Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, Justin Kolb, Siegfried Labeit and Henk Granzier |
| Zusammenfassung: | Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice. |
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| Beschreibung: | Gesehen am 28.08.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01144-9 |