Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum...

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Hauptverfasser: Boldescu, Veaceslav (VerfasserIn) , Behnam, Mira A. M. (VerfasserIn) , Klein, Christian D. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 May 2017
In: Nature reviews. Drug discovery
Year: 2017, Jahrgang: 16, Heft: 8, Pages: 565-586
ISSN:1474-1784
DOI:10.1038/nrd.2017.33
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/nrd.2017.33
Verlag, Volltext: https://www.nature.com/articles/nrd.2017.33
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Verfasserangaben:Veaceslav Boldescu, Mira A.M. Behnam, Nikos Vasilakis, Christian D. Klein

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520 |a Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets. 
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