Polygenic risk for depression and the neural correlates of working memory in healthy subjects
Introduction: Major depressive disorder (MDD) patients show impairments of cognitive functioning such as working memory (WM), and furthermore alterations during WM-fMRI tasks especially in frontal and parietal brain regions. The calculation of a polygenic risk score (PRS) can be used to describe the...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 June 2017
|
| In: |
Progress in neuro-psychopharmacology & biological psychiatry
Year: 2017, Jahrgang: 79, Pages: 67-76 |
| ISSN: | 1878-4216 |
| DOI: | 10.1016/j.pnpbp.2017.06.010 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.pnpbp.2017.06.010 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0278584617301537 
|
| Verfasserangaben: | Dilara Yüksel, Bruno Dietsche, Andreas J. Forstner, Stephanie H. Witt, Robert Maier, Marcella Rietschel, Carsten Konrad, Markus M. Nöthen, Udo Dannlowski, Bernhard T. Baune, Tilo Kircher, Axel Krug |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580513239 | ||
| 003 | DE-627 | ||
| 005 | 20220814235144.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180829s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pnpbp.2017.06.010 |2 doi | |
| 035 | |a (DE-627)1580513239 | ||
| 035 | |a (DE-576)510513239 | ||
| 035 | |a (DE-599)BSZ510513239 | ||
| 035 | |a (OCoLC)1341017919 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Yueksel, Dilara |e VerfasserIn |0 (DE-588)1165692767 |0 (DE-627)1029778809 |0 (DE-576)510513700 |4 aut | |
| 245 | 1 | 0 | |a Polygenic risk for depression and the neural correlates of working memory in healthy subjects |c Dilara Yüksel, Bruno Dietsche, Andreas J. Forstner, Stephanie H. Witt, Robert Maier, Marcella Rietschel, Carsten Konrad, Markus M. Nöthen, Udo Dannlowski, Bernhard T. Baune, Tilo Kircher, Axel Krug |
| 264 | 1 | |c 15 June 2017 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.08.2018 | ||
| 500 | |a Available online 15 June 2017 | ||
| 520 | |a Introduction: Major depressive disorder (MDD) patients show impairments of cognitive functioning such as working memory (WM), and furthermore alterations during WM-fMRI tasks especially in frontal and parietal brain regions. The calculation of a polygenic risk score (PRS) can be used to describe the genetic influence on MDD, hence imaging genetic studies aspire to combine both genetics and neuroimaging data to identify the influence of genetic factors on brain functioning. We aimed to detect the effect of MDD-PRS on brain activation during a WM task measured with fMRI and expect healthy individuals with a higher PRS to be more resembling to MDD patients. Method: In total, n=137 (80 men, 57 women, aged 34.5, SD=10.4years) healthy subjects performed a WM n-back task [0-back (baseline), 2-back and 3-back condition] in a 3T-MRI-tomograph. The sample was genotyped using the Infinium PsychArray BeadChip and a polygenic risk score was calculated for MDD using PGC MDD GWAS results. Results: A lower MDD risk score was associated with increased activation in the bilateral middle occipital gyri (MOG), the bilateral middle frontal gyri (MFG) and the right precentral gyrus (PCG) during the 2-back vs. baseline condition. Moreover, a lower PRS was associated with increased brain activation during the 3-back vs. baseline condition in the bilateral cerebellum, the right MFG and the left inferior parietal lobule. A higher polygenic risk score was associated with hyperactivation in brain regions comprising the right MFG and the right supplementary motor area during the 3-back vs. 2-back condition. Discussion: The results suggest that part of the WM-related brain activation patterns might be explained by genetic variants captured by the MDD-PRS. Furthermore we were able to detect MDD-associated activation patterns in healthy individuals depending on the MDD-PRS and the task complexity. Additional gene loci could contribute to these task-dependent brain activation patterns. | ||
| 650 | 4 | |a fMRI | |
| 650 | 4 | |a Imaging genetics | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a Polygenic risk for depression | |
| 650 | 4 | |a Working memory | |
| 700 | 1 | |a Witt, Stephanie |d 1970- |e VerfasserIn |0 (DE-588)132177897 |0 (DE-627)519022432 |0 (DE-576)298988399 |4 aut | |
| 700 | 1 | |a Rietschel, Marcella |d 1957- |e VerfasserIn |0 (DE-588)112785751 |0 (DE-627)505574020 |0 (DE-576)289742307 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Progress in neuro-psychopharmacology & biological psychiatry |d Amsterdam [u.a.] : Elsevier Science, 1982 |g 79(2017), Seite 67-76 |h Online-Ressource |w (DE-627)320473252 |w (DE-600)2008803-6 |w (DE-576)099879026 |x 1878-4216 |7 nnas |a Polygenic risk for depression and the neural correlates of working memory in healthy subjects |
| 773 | 1 | 8 | |g volume:79 |g year:2017 |g pages:67-76 |g extent:10 |a Polygenic risk for depression and the neural correlates of working memory in healthy subjects |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pnpbp.2017.06.010 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0278584617301537 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180829 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 112785751 |a Rietschel, Marcella |m 112785751:Rietschel, Marcella |d 60000 |e 60000PR112785751 |k 0/60000/ |p 6 | ||
| 998 | |g 132177897 |a Witt, Stephanie |m 132177897:Witt, Stephanie |d 60000 |e 60000PW132177897 |k 0/60000/ |p 4 | ||
| 999 | |a KXP-PPN1580513239 |e 302414790X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Dilara Yüksel, Bruno Dietsche, Andreas J. Forstner, Stephanie H. Witt, Robert Maier, Marcella Rietschel, Carsten Konrad, Markus M. Nöthen, Udo Dannlowski, Bernhard T. Baune, Tilo Kircher, Axel Krug"]},"person":[{"family":"Yueksel","given":"Dilara","role":"aut","display":"Yueksel, Dilara"},{"display":"Witt, Stephanie","given":"Stephanie","role":"aut","family":"Witt"},{"display":"Rietschel, Marcella","role":"aut","given":"Marcella","family":"Rietschel"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1580513239","origin":[{"dateIssuedDisp":"15 June 2017","dateIssuedKey":"2017"}],"id":{"eki":["1580513239"],"doi":["10.1016/j.pnpbp.2017.06.010"]},"physDesc":[{"extent":"10 S."}],"note":["Gesehen am 29.08.2018","Available online 15 June 2017"],"relHost":[{"title":[{"title_sort":"Progress in neuro-psychopharmacology & biological psychiatry","title":"Progress in neuro-psychopharmacology & biological psychiatry","subtitle":"an international research, review, and news journal"}],"part":{"pages":"67-76","extent":"10","year":"2017","text":"79(2017), Seite 67-76","volume":"79"},"language":["eng"],"pubHistory":["6.1982 -"],"disp":"Polygenic risk for depression and the neural correlates of working memory in healthy subjectsProgress in neuro-psychopharmacology & biological psychiatry","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["320473252"],"zdb":["2008803-6"],"issn":["1878-4216"]},"note":["Gesehen am 20.02.20"],"titleAlt":[{"title":"Progress in neuro-psychopharmacology and biological psychiatry"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"1982","dateIssuedDisp":"1982-","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}],"recId":"320473252"}],"title":[{"title_sort":"Polygenic risk for depression and the neural correlates of working memory in healthy subjects","title":"Polygenic risk for depression and the neural correlates of working memory in healthy subjects"}],"language":["eng"]} | ||
| SRT | |a YUEKSELDILPOLYGENICR1520 | ||