Use of evidence-based recommendations in an antibiotic care bundle for the intensive care unit
Purpose: To drive decisions on antibiotic therapy in the intensive care unit (ICU), we developed an antibiotic care bundle (ABC-Bundle) with evidence-based recommendations (EBRs) for antibiotic prescriptions. Methods: We conducted a three-step prospective study. First, a systematic review was perfor...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
International journal of antimicrobial agents
Year: 2017, Volume: 51, Issue: 1, Pages: 65-70 |
| ISSN: | 1872-7913 |
| DOI: | 10.1016/j.ijantimicag.2017.06.020 |
| Online Access: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1016/j.ijantimicag.2017.06.020 Verlag, Pay-per-use, Volltext: http://www.sciencedirect.com/science/article/pii/S0924857917302698 
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| Author Notes: | Nico T. Mutters, Giulia De Angelis, Giovanni Restuccia, Francesca Di Muzio, Jeroen Schouten, Marlies Hulscher, Massimo Antonelli, Evelina Tacconelli |
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| 245 | 1 | 0 | |a Use of evidence-based recommendations in an antibiotic care bundle for the intensive care unit |c Nico T. Mutters, Giulia De Angelis, Giovanni Restuccia, Francesca Di Muzio, Jeroen Schouten, Marlies Hulscher, Massimo Antonelli, Evelina Tacconelli |
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| 520 | |a Purpose: To drive decisions on antibiotic therapy in the intensive care unit (ICU), we developed an antibiotic care bundle (ABC-Bundle) with evidence-based recommendations (EBRs) for antibiotic prescriptions. Methods: We conducted a three-step prospective study. First, a systematic review was performed of the literature reporting EBRs for antibiotic usage in the ICU. Second, we developed an ABC-Bundle through a two-round, RAND-modified Delphi method with an international expert panel, including the most relevant EBRs on a 9-point Likert scale. Those EBRs that were considered mandatory by >50% of the experts were included in the bundle. Third, we assessed the adherence to and applicability of the bundle in two mixed university ICUs. Results: Out of 1190 potentially relevant articles, 14 (four guidelines, four randomised controlled trials and six systematic reviews) fulfilled the eligibility criteria. Six EBRs were classified as relevant: 1. Provide rationale for antibiotic start; 2. Perform appropriate microbiological sampling; 3. Prescribe empirical antibiotic therapy according to guidelines (Day 1); 4. Review diagnosis; 5. Evaluate de-escalation based on microbiological results (Days 2-5); and 6. Consider discontinuation of treatment (Days 3-5). Daily adherence to the ABC-Bundle, prospectively assessed in 861 days of therapy in 142 ICU patients, ranged from 2% to 37%. Conclusion: The ABC-Bundle is a novel tool to improve delivery of appropriate antibiotic therapy to ICU patients. The low adherence in the prospective cohorts confirms the significant role that the ABC-Bundle could play in an antibiotic stewardship programme in the ICU setting. | ||
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| 650 | 4 | |a Antibiotic prescription | |
| 650 | 4 | |a Antimicrobial resistance | |
| 650 | 4 | |a Antimicrobial therapy | |
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| 650 | 4 | |a ICU | |
| 650 | 4 | |a Infectious diseases | |
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