SUMO unloads the Kap114 cab
Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines com...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 May 2012
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| In: |
The EMBO journal
Year: 2012, Jahrgang: 31, Heft: 11, Pages: 2439-2440 |
| ISSN: | 1460-2075 |
| DOI: | 10.1038/emboj.2012.103 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/emboj.2012.103 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.1038/emboj.2012.103 
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| Verfasserangaben: | Andreas Werner and Frauke Melchior |
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| 520 | |a Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines compartment-specific interactions between receptors and their cargo. In this issue of The EMBO Journal, Rothenbusch et al (2012) now add a new energy-dependent event to this basic pathway by providing direct evidence that the posttranslational modification of the yeast import receptor Kap114 with small ubiquitin-related modifier (SUMO) is indispensable for its correct function. An exciting model emerges in which Kap114 sumoylation regulates Ran-dependent cargo release, and thereby acts as a mechanism for intranuclear targeting of the import cargo. | ||
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