Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane1. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembra...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
9 January 2012
|
| In: |
Nature
Year: 2012, Jahrgang: 481, Heft: 7382, Pages: 525-529 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature10742 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/nature10742 Verlag, Volltext: https://www.nature.com/articles/nature10742 
|
| Verfasserangaben: | F.-Xabier Contreras, Andreas M. Ernst, Per Haberkant, Patrik Björkholm, Erik Lindahl, Başak Gönen, Christian Tischer, Arne Elofsson, Gunnar von Heijne, Christoph Thiele, Rainer Pepperkok, Felix Wieland & Britta Brügger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580649483 | ||
| 003 | DE-627 | ||
| 005 | 20220815001433.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180904s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/nature10742 |2 doi | |
| 035 | |a (DE-627)1580649483 | ||
| 035 | |a (DE-576)510649483 | ||
| 035 | |a (DE-599)BSZ510649483 | ||
| 035 | |a (OCoLC)1341017770 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Contreras, F. Xabier |e VerfasserIn |0 (DE-588)1156239907 |0 (DE-627)1018704310 |0 (DE-576)502053208 |4 aut | |
| 245 | 1 | 0 | |a Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain |c F.-Xabier Contreras, Andreas M. Ernst, Per Haberkant, Patrik Björkholm, Erik Lindahl, Başak Gönen, Christian Tischer, Arne Elofsson, Gunnar von Heijne, Christoph Thiele, Rainer Pepperkok, Felix Wieland & Britta Brügger |
| 264 | 1 | |c 9 January 2012 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.09.2018 | ||
| 520 | |a Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane1. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of proteins within the hydrophobic bilayer, and how this could affect protein function. Here we show a direct and highly specific interaction of exclusively one sphingomyelin species, SM 18, with the TMD of the COPI machinery protein p24 (ref. 2). Strikingly, the interaction depends on both the headgroup and the backbone of the sphingolipid, and on a signature sequence (VXXTLXXIY) within the TMD. Molecular dynamics simulations show a close interaction of SM 18 with the TMD. We suggest a role of SM 18 in regulating the equilibrium between an inactive monomeric and an active oligomeric state of the p24 protein3,4, which in turn regulates COPI-dependent transport. Bioinformatic analyses predict that the signature sequence represents a conserved sphingolipid-binding cavity in a variety of mammalian membrane proteins. Thus, in addition to a function as second messengers, sphingolipids can act as cofactors to regulate the function of transmembrane proteins. Our discovery of an unprecedented specificity of interaction of a TMD with an individual sphingolipid species adds to our understanding of why biological membranes are assembled from such a large variety of different lipids. | ||
| 700 | 1 | |a Ernst, Andreas M. |e VerfasserIn |0 (DE-588)1035799960 |0 (DE-627)749589884 |0 (DE-576)383562503 |4 aut | |
| 700 | 1 | |a Haberkant, Per |e VerfasserIn |0 (DE-588)132695928 |0 (DE-627)525526854 |0 (DE-576)299350150 |4 aut | |
| 700 | 1 | |a Pepperkok, Rainer |e VerfasserIn |0 (DE-588)1150711302 |0 (DE-627)1010920588 |0 (DE-576)497195461 |4 aut | |
| 700 | 1 | |a Wieland, Felix T. |d 1948- |e VerfasserIn |0 (DE-588)1020541881 |0 (DE-627)69125365X |0 (DE-576)360684009 |4 aut | |
| 700 | 1 | |a Brügger, Britta |d 1969- |e VerfasserIn |0 (DE-588)121046028 |0 (DE-627)081051743 |0 (DE-576)292514492 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature |d London [u.a.] : Nature Publ. Group, 1869 |g 481(2012), 7382, Seite 525-529 |h Online-Ressource |w (DE-627)240151402 |w (DE-600)1413423-8 |w (DE-576)079718426 |x 1476-4687 |7 nnas |a Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain |
| 773 | 1 | 8 | |g volume:481 |g year:2012 |g number:7382 |g pages:525-529 |g extent:5 |a Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/nature10742 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/nature10742 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180904 | ||
| 993 | |a Editorial | ||
| 994 | |a 2012 | ||
| 998 | |g 121046028 |a Brügger, Britta |m 121046028:Brügger, Britta |d 700000 |d 711000 |d 700000 |d 718000 |e 700000PB121046028 |e 711000PB121046028 |e 700000PB121046028 |e 718000PB121046028 |k 0/700000/ |k 1/700000/711000/ |k 0/700000/ |k 1/700000/718000/ |p 13 |y j | ||
| 998 | |g 1020541881 |a Wieland, Felix T. |m 1020541881:Wieland, Felix T. |d 700000 |d 711000 |d 700000 |d 718000 |e 700000PW1020541881 |e 711000PW1020541881 |e 700000PW1020541881 |e 718000PW1020541881 |k 0/700000/ |k 1/700000/711000/ |k 0/700000/ |k 1/700000/718000/ |p 12 | ||
| 998 | |g 1150711302 |a Pepperkok, Rainer |m 1150711302:Pepperkok, Rainer |d 700000 |d 718000 |e 700000PP1150711302 |e 718000PP1150711302 |k 0/700000/ |k 1/700000/718000/ |p 11 | ||
| 998 | |g 132695928 |a Haberkant, Per |m 132695928:Haberkant, Per |d 700000 |d 711000 |e 700000PH132695928 |e 711000PH132695928 |k 0/700000/ |k 1/700000/711000/ |p 3 | ||
| 998 | |g 1035799960 |a Ernst, Andreas M. |m 1035799960:Ernst, Andreas M. | ||
| 998 | |g 1156239907 |a Contreras, F. Xabier |m 1156239907:Contreras, F. Xabier |d 700000 |d 711000 |e 700000PC1156239907 |e 711000PC1156239907 |k 0/700000/ |k 1/700000/711000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580649483 |e 3024683550 | ||
| BIB | |a Y | ||
| SER | |a newspaper | ||
| JSO | |a {"note":["Gesehen am 04.09.2018"],"relHost":[{"note":["Gesehen am 19.02.2019"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"5","issue":"7382","year":"2012","pages":"525-529","volume":"481","text":"481(2012), 7382, Seite 525-529"},"id":{"eki":["240151402"],"issn":["1476-4687"],"zdb":["1413423-8"]},"title":[{"title":"Nature","subtitle":"international weekly journal of science","title_sort":"Nature"}],"origin":[{"dateIssuedDisp":"1869-","publisher":"Nature Publ. Group ; Macmillan","publisherPlace":"London [u.a.] ; London","dateIssuedKey":"1869"}],"type":{"media":"Online-Ressource","bibl":"newspaper"},"pubHistory":["1.1869/70 - ; auch mit durchgehender Nr.-Zählung"],"language":["eng"],"titleAlt":[{"title":"Nature <London>"},{"title":"Nature"}],"recId":"240151402","disp":"Molecular recognition of a single sphingolipid species by a protein’s transmembrane domainNature"}],"id":{"eki":["1580649483"],"doi":["10.1038/nature10742"]},"type":{"bibl":"article-newspaper","media":"Online-Ressource"},"physDesc":[{"extent":"5 S."}],"title":[{"title_sort":"Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain","title":"Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain"}],"language":["eng"],"name":{"displayForm":["F.-Xabier Contreras, Andreas M. Ernst, Per Haberkant, Patrik Björkholm, Erik Lindahl, Başak Gönen, Christian Tischer, Arne Elofsson, Gunnar von Heijne, Christoph Thiele, Rainer Pepperkok, Felix Wieland & Britta Brügger"]},"origin":[{"dateIssuedDisp":"9 January 2012","dateIssuedKey":"2012"}],"recId":"1580649483","person":[{"family":"Contreras","given":"F. Xabier","display":"Contreras, F. Xabier","role":"aut"},{"role":"aut","family":"Ernst","display":"Ernst, Andreas M.","given":"Andreas M."},{"given":"Per","display":"Haberkant, Per","family":"Haberkant","role":"aut"},{"family":"Pepperkok","display":"Pepperkok, Rainer","given":"Rainer","role":"aut"},{"role":"aut","family":"Wieland","display":"Wieland, Felix T.","given":"Felix T."},{"role":"aut","display":"Brügger, Britta","given":"Britta","family":"Brügger"}]} | ||
| SRT | |a CONTRERASFMOLECULARR9201 | ||