Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting: a consequence of microcirculatory alterations?
BACKGROUND: In this study we aimed to evaluate the effects of dilutional anemia resulting from cardiopulmonary bypass (CPB) and its correction with red blood cell (RBC) transfusion on tissue oxygenation and renal function in diabetic patients undergoing coronary artery bypass grafting (CABG). METHOD...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
|
| In: |
Journal of nephrology
Year: 2017, Jahrgang: 31, Heft: 3, Pages: 417-422 |
| ISSN: | 1724-6059 |
| DOI: | 10.1007/s40620-017-0388-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: http://dx.doi.org/10.1007/s40620-017-0388-8
|
| Verfasserangaben: | Güçlü Aykut, Meltem Kilercik, Cem Arıtürk, Halim Ulugöl, Uğur Aksu, Türkan Kudsioğlu, Nazan Atalan, Nihan Yapıcı, Hasan Karabulut, Fevzi Toraman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580649807 | ||
| 003 | DE-627 | ||
| 005 | 20220815001440.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180904r20182017xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s40620-017-0388-8 |2 doi | |
| 035 | |a (DE-627)1580649807 | ||
| 035 | |a (DE-576)510649807 | ||
| 035 | |a (DE-599)BSZ510649807 | ||
| 035 | |a (OCoLC)1341018043 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Aykut, Güçlü |d 1969- |e VerfasserIn |0 (DE-588)138404968 |0 (DE-627)696595826 |0 (DE-576)307165086 |4 aut | |
| 245 | 1 | 0 | |a Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting |b a consequence of microcirculatory alterations? |c Güçlü Aykut, Meltem Kilercik, Cem Arıtürk, Halim Ulugöl, Uğur Aksu, Türkan Kudsioğlu, Nazan Atalan, Nihan Yapıcı, Hasan Karabulut, Fevzi Toraman |
| 264 | 1 | |c 2018 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First online: 22 March 2017 | ||
| 500 | |a Gesehen am 04.09.2018 | ||
| 520 | |a BACKGROUND: In this study we aimed to evaluate the effects of dilutional anemia resulting from cardiopulmonary bypass (CPB) and its correction with red blood cell (RBC) transfusion on tissue oxygenation and renal function in diabetic patients undergoing coronary artery bypass grafting (CABG). METHOD: 70 diabetic patients who underwent elective CABG and whose hematocrit values had been between 24-28% at any time during CBP were prospectively randomized and equally allocated to two groups: patients who received RBC during CPB (group I, n = 35) vs. did not receive RBC during CPB (group II, n = 35). Besides routine hemodynamic and biochemical parameters, biomarkers of ischemia and renal injury such as ischemia modified albumin (IMA), protein oxidation parameters [advanced oxidative protein products (AOPP), total thiol (T-SH)], neutrophil gelatinase-associated lipocalin (NGAL) and estimated glomerular filtration rate (eGFR) were measured in both groups. RESULTS: In group I, T-SH, NGAL and urea levels were found to be significantly increased postoperatively compared to preoperative measurements (p < 0.05). Also, postoperatively, NGAL, creatinine, aspartate aminotransferase and AOPP levels were higher in group I than group II (p < 0.05). CONCLUSION: The correction of anemia with RBC transfusion in diabetic patients undergoing CABG could increase the risk of renal injury. Further studies verifying the effects of blood transfusions at the microcirculatory level are needed to optimize the efficacy of transfusions. | ||
| 534 | |c 2017 | ||
| 650 | 4 | |a Acute kidney dysfunction | |
| 650 | 4 | |a Cardiac surgery | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a Microcirculation | |
| 650 | 4 | |a Transfusion | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of nephrology |d Milano : Springer, 1996 |g 31(2018), 3, Seite 417-422 |h Online-Ressource |w (DE-627)269534512 |w (DE-600)1475007-7 |w (DE-576)100800513 |x 1724-6059 |7 nnas |a Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting a consequence of microcirculatory alterations? |
| 773 | 1 | 8 | |g volume:31 |g year:2018 |g number:3 |g pages:417-422 |g extent:6 |a Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting a consequence of microcirculatory alterations? |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s40620-017-0388-8 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180904 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 138404968 |a Aykut, Güçlü |m 138404968:Aykut, Güçlü |d 910000 |d 910300 |e 910000PA138404968 |e 910300PA138404968 |k 0/910000/ |k 1/910000/910300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580649807 |e 3024685669 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Aykut","given":"Güçlü","display":"Aykut, Güçlü","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title_sort":"Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting","title":"Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting","subtitle":"a consequence of microcirculatory alterations?"}],"note":["First online: 22 March 2017","Gesehen am 04.09.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1580649807","language":["eng"],"name":{"displayForm":["Güçlü Aykut, Meltem Kilercik, Cem Arıtürk, Halim Ulugöl, Uğur Aksu, Türkan Kudsioğlu, Nazan Atalan, Nihan Yapıcı, Hasan Karabulut, Fevzi Toraman"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"2018"}],"id":{"eki":["1580649807"],"doi":["10.1007/s40620-017-0388-8"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Società Italiana Nefrologia"]},"id":{"zdb":["1475007-7"],"eki":["269534512"],"issn":["1724-6059"]},"origin":[{"publisherPlace":"Milano ; Milano","dateIssuedDisp":"1996-","dateIssuedKey":"1996","publisher":"Springer ; Wichtig"}],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Società Italiana di Nefrologia","role":"isb"}],"language":["eng"],"recId":"269534512","type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting a consequence of microcirculatory alterations?Journal of nephrology","note":["Gesehen am 14.02.2025","Fortsetzung der Druck-Ausgabe"],"titleAlt":[{"title":"JN"}],"part":{"volume":"31","text":"31(2018), 3, Seite 417-422","extent":"6","year":"2018","issue":"3","pages":"417-422"},"pubHistory":["Nachgewiesen 9.1996 -"],"title":[{"subtitle":"JN","title":"Journal of nephrology","title_sort":"Journal of nephrology"}]}]} | ||
| SRT | |a AYKUTGUECLCORRECTION2018 | ||