Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation
Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different phases in the establishment of antitumor immune re...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017 Jan 31
|
| In: |
OncoImmunology
Year: 2017, Volume: 6, Issue: 4 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2017.1285992 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1080/2162402X.2017.1285992 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414860/ 
|
| Author Notes: | Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, and Christine E. Engeland |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580706851 | ||
| 003 | DE-627 | ||
| 005 | 20220815002506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180905s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/2162402X.2017.1285992 |2 doi | |
| 035 | |a (DE-627)1580706851 | ||
| 035 | |a (DE-576)510706851 | ||
| 035 | |a (DE-599)BSZ510706851 | ||
| 035 | |a (OCoLC)1341017939 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Veinalde, Rūta |e VerfasserIn |0 (DE-588)1136804471 |0 (DE-627)893597589 |0 (DE-576)490853757 |4 aut | |
| 245 | 1 | 0 | |a Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation |c Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, and Christine E. Engeland |
| 264 | 1 | |c 2017 Jan 31 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.09.2018 | ||
| 520 | |a Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different phases in the establishment of antitumor immune responses. Therapeutic efficacy of the novel vectors was evaluated in the immunocompetent MC38cea tumor model. We identified vectors encoding an IL-12 fusion protein (MeVac FmIL-12) and an antibody against PD-L1 (MeVac anti-PD-L1), respectively, as the most effective. Treatment of established tumors with MeVac FmIL-12 achieved 90% complete remissions. Profiling of the tumor immune microenvironment revealed activation of a type 1 T helper cell-directed response, with MeVac FmIL-12 ensuring potent early natural killer and effector T cell activation as well as upregulation of the effector cytokines IFN-γ and TNF-α. CD8+ T cells were found to be essential for the therapeutic efficacy of MeVac FmIL-12. Results of this study present MeVac FmIL-12 as a novel approach for targeted IL-12 delivery and elucidate mechanisms of successful immunovirotherapy. | ||
| 700 | 1 | |a Großardt, Christian |e VerfasserIn |0 (DE-588)1044668512 |0 (DE-627)772407045 |0 (DE-576)398026408 |4 aut | |
| 700 | 1 | |a Hartmann, Laura |d 1990- |e VerfasserIn |0 (DE-588)1166276864 |0 (DE-627)1030288763 |0 (DE-576)51070672X |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Kalle, Christof von |d 1962- |e VerfasserIn |0 (DE-588)1036481115 |0 (DE-627)75107926X |0 (DE-576)168957396 |4 aut | |
| 700 | 1 | |a Ungerechts, Guy |d 1972- |e VerfasserIn |0 (DE-588)124557902 |0 (DE-627)363420053 |0 (DE-576)294230939 |4 aut | |
| 700 | 1 | |a Engeland, Christine Elisabeth |d 1985- |e VerfasserIn |0 (DE-588)1025405951 |0 (DE-627)722221193 |0 (DE-576)370314670 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoImmunology |d Abingdon : Taylor & Franics, 2012 |g 6(2017,4) Artikel-Nummer e1285992, 11 Seiten |h Online-Ressource |w (DE-627)683365428 |w (DE-600)2645309-5 |w (DE-576)356728366 |x 2162-402X |7 nnas |a Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation |
| 773 | 1 | 8 | |g volume:6 |g year:2017 |g number:4 |g extent:11 |a Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/2162402X.2017.1285992 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414860/ |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180905 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1025405951 |a Engeland, Christine Elisabeth |m 1025405951:Engeland, Christine Elisabeth |d 910000 |e 910000PE1025405951 |k 0/910000/ |p 9 |y j | ||
| 998 | |g 124557902 |a Ungerechts, Guy |m 124557902:Ungerechts, Guy |d 910000 |e 910000PU124557902 |k 0/910000/ |p 8 | ||
| 998 | |g 1036481115 |a Kalle, Christof von |m 1036481115:Kalle, Christof von |d 910000 |d 700000 |d 718000 |e 910000PK1036481115 |e 700000PK1036481115 |e 718000PK1036481115 |k 0/910000/ |k 0/700000/ |k 1/700000/718000/ |p 7 | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 6 | ||
| 998 | |g 1166276864 |a Hartmann, Laura |m 1166276864:Hartmann, Laura |d 140000 |e 140000PH1166276864 |k 0/140000/ |p 3 | ||
| 998 | |g 1044668512 |a Großardt, Christian |m 1044668512:Großardt, Christian |d 910000 |e 910000PG1044668512 |k 0/910000/ |p 2 | ||
| 998 | |g 1136804471 |a Veinalde, Rūta |m 1136804471:Veinalde, Rūta |d 910000 |e 910000PV1136804471 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580706851 |e 302478196X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"language":["eng"],"titleAlt":[{"title":"Onco Immunology"}],"recId":"683365428","disp":"Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activationOncoImmunology","pubHistory":["1.2012 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"OncoImmunology","title_sort":"OncoImmunology"}],"origin":[{"dateIssuedDisp":"2012-","publisher":"Taylor & Franics ; Landes Bioscience","publisherPlace":"Abingdon ; Austin, Tex.","dateIssuedKey":"2012"}],"note":["Gesehen am 13.12.2022"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["683365428"],"issn":["2162-402X"],"zdb":["2645309-5"]},"part":{"year":"2017","extent":"11","issue":"4","volume":"6","text":"6(2017,4) Artikel-Nummer e1285992, 11 Seiten"}}],"note":["Gesehen am 05.09.2018"],"physDesc":[{"extent":"11 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1580706851"],"doi":["10.1080/2162402X.2017.1285992"]},"language":["eng"],"title":[{"title_sort":"Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation","title":"Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation"}],"person":[{"role":"aut","display":"Veinalde, Rūta","given":"Rūta","family":"Veinalde"},{"role":"aut","family":"Großardt","display":"Großardt, Christian","given":"Christian"},{"role":"aut","given":"Laura","display":"Hartmann, Laura","family":"Hartmann"},{"role":"aut","given":"Dirk","display":"Jäger, Dirk","family":"Jäger"},{"given":"Christof von","display":"Kalle, Christof von","family":"Kalle","role":"aut"},{"display":"Ungerechts, Guy","given":"Guy","family":"Ungerechts","role":"aut"},{"role":"aut","family":"Engeland","display":"Engeland, Christine Elisabeth","given":"Christine Elisabeth"}],"recId":"1580706851","name":{"displayForm":["Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, and Christine E. Engeland"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"2017 Jan 31"}]} | ||
| SRT | |a VEINALDERUONCOLYTICM2017 | ||