Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation
Patient-derived cancer xenografts (PDX) are widely used to identify and evaluate novel therapeutic targets, and to test therapeutic approaches in preclinical mouse avatar trials. Despite their widespread use, potential caveats of PDX models remain considerably underappreciated. Here, we demonstrate...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
International journal of cancer
Year: 2017, Jahrgang: 140, Heft: 6, Pages: 1356-1363 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.30561 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/ijc.30561 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.30561 
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| Verfasserangaben: | Sebastian M. Dieter, Klara M. Giessler, Mark Kriegsmann, Taronish D. Dubash, Lino Möhrmann, Erik R. Schulz, Christine Siegl, Sarah Weber, Hendrik Strakerjahn, Ava Oberlack, Ulrike Heger, Jianpeng Gao, Eva-Maria Hartinger, Felix Oppel, Christopher M. Hoffmann, Nati Ha, Benedikt Brors, Felix Lasitschka, Alexis Ulrich, Oliver Strobel, Manfred Schmidt, Christof von Kalle, Martin Schneider, Wilko Weichert, K. Roland Ehrenberg, Hanno Glimm and Claudia R. Ball |
MARC
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| 245 | 1 | 0 | |a Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation |c Sebastian M. Dieter, Klara M. Giessler, Mark Kriegsmann, Taronish D. Dubash, Lino Möhrmann, Erik R. Schulz, Christine Siegl, Sarah Weber, Hendrik Strakerjahn, Ava Oberlack, Ulrike Heger, Jianpeng Gao, Eva-Maria Hartinger, Felix Oppel, Christopher M. Hoffmann, Nati Ha, Benedikt Brors, Felix Lasitschka, Alexis Ulrich, Oliver Strobel, Manfred Schmidt, Christof von Kalle, Martin Schneider, Wilko Weichert, K. Roland Ehrenberg, Hanno Glimm and Claudia R. Ball |
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| 520 | |a Patient-derived cancer xenografts (PDX) are widely used to identify and evaluate novel therapeutic targets, and to test therapeutic approaches in preclinical mouse avatar trials. Despite their widespread use, potential caveats of PDX models remain considerably underappreciated. Here, we demonstrate that EBV-associated B-lymphoproliferations frequently develop following xenotransplantation of human colorectal and pancreatic carcinomas in highly immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice (18/47 and 4/37 mice, respectively), and in derived cell cultures in vitro. Strikingly, even PDX with carcinoma histology can host scarce EBV-infected B-lymphocytes that can fully overgrow carcinoma cells during serial passaging in vitro and in vivo. As serial xenografting is crucial to expand primary tumor tissue for biobanks and cohorts for preclinical mouse avatar trials, the emerging dominance of B-lymphoproliferations in serial PDX represents a serious confounding factor in these models. Consequently, repeated phenotypic assessments of serial PDX are mandatory at each expansion step to verify “bona fide” carcinoma xenografts. | ||
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a lymphoproliferation | |
| 650 | 4 | |a pancreatic cancer | |
| 650 | 4 | |a patient-derived xenograft | |
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