Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery: a systematic review and meta-analysis of preclinical studies
Limited regeneration after nerve injury often leads to delayed or incomplete reinnervation and consequently insufficient muscle function. Following nerve surgery, application of low-intensity ultrasound or extracorporeal shock waves may promote nerve regeneration and improve functional outcomes. Bec...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 February 2018
|
| In: |
Scientific reports
Year: 2018, Volume: 8 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-21540-5 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41598-018-21540-5 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-018-21540-5 
|
| Author Notes: | Simeon C. Daeschler, Leila Harhaus, Philipp Schoenle, Arne Boecker, Ulrich Kneser, Konstantin D. Bergmeister |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580827497 | ||
| 003 | DE-627 | ||
| 005 | 20210815212702.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180910s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-018-21540-5 |2 doi | |
| 035 | |a (DE-627)1580827497 | ||
| 035 | |a (DE-576)510827497 | ||
| 035 | |a (DE-599)BSZ510827497 | ||
| 035 | |a (OCoLC)1264006408 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Däschler, Simeon C. |d 1991- |e VerfasserIn |0 (DE-588)1166617173 |0 (DE-627)1030514984 |0 (DE-576)510826733 |4 aut | |
| 245 | 1 | 0 | |a Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery |b a systematic review and meta-analysis of preclinical studies |c Simeon C. Daeschler, Leila Harhaus, Philipp Schoenle, Arne Boecker, Ulrich Kneser, Konstantin D. Bergmeister |
| 264 | 1 | |c 16 February 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.09.2018 | ||
| 520 | |a Limited regeneration after nerve injury often leads to delayed or incomplete reinnervation and consequently insufficient muscle function. Following nerve surgery, application of low-intensity ultrasound or extracorporeal shock waves may promote nerve regeneration and improve functional outcomes. Because currently clinical data is unavailable, we performed a meta-analysis following the PRISMA-guidelines to investigate the therapeutic effect of ultrasound and shock wave therapies on motor nerve regeneration. Ten ultrasound-studies (N = 445 rats) and three shock-wave studies (N = 110 rats) were identified from multiple databases. We calculated the difference in means or standardized mean difference with 95% confidence intervals for motor function, nerve conduction velocity and histomorphological parameters of treated versus sham or non-treated animals. Ultrasound treatment showed significantly faster nerve conduction, increased axonal regeneration with thicker myelin and improved motor function on sciatic functional index scale (week two: DM[95%CI]: 19,03[13,2 to 25,6], 71 animals; week four: 7,4[5,4 to 9,5], 47 animals). Shock wave induced recovery improvements were temporarily significant. In conclusion, there is significant evidence for low-intensity ultrasound but not for extracorporeal shock wave treatment to improve nerve regeneration. Prospective clinical trials should therefore investigate available FDA-approved ultrasound devices as adjunct postoperative treatment following nerve surgery. | ||
| 700 | 1 | |a Harhaus-Wähner, Leila |d 1980- |e VerfasserIn |0 (DE-588)132529874 |0 (DE-627)523625944 |0 (DE-576)299205185 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 8(2018) Artikel-Nummer 3168, 11 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery a systematic review and meta-analysis of preclinical studies |
| 773 | 1 | 8 | |g volume:8 |g year:2018 |a Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery a systematic review and meta-analysis of preclinical studies |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-018-21540-5 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-018-21540-5 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180910 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 132529874 |a Harhaus-Wähner, Leila |m 132529874:Harhaus-Wähner, Leila |d 50000 |e 50000PH132529874 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1580827497 |e 3025217944 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Simeon C. Daeschler, Leila Harhaus, Philipp Schoenle, Arne Boecker, Ulrich Kneser, Konstantin D. Bergmeister"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"16 February 2018"}],"recId":"1580827497","person":[{"role":"aut","family":"Däschler","given":"Simeon C.","display":"Däschler, Simeon C."},{"role":"aut","family":"Harhaus-Wähner","given":"Leila","display":"Harhaus-Wähner, Leila"}],"title":[{"title_sort":"Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery","subtitle":"a systematic review and meta-analysis of preclinical studies","title":"Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery"}],"language":["eng"],"id":{"eki":["1580827497"],"doi":["10.1038/s41598-018-21540-5"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 10.09.2018"],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1, article number 1 (2011)-"],"recId":"663366712","disp":"Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery a systematic review and meta-analysis of preclinical studiesScientific reports","language":["eng"],"part":{"year":"2018","text":"8(2018) Artikel-Nummer 3168, 11 Seiten","volume":"8"},"id":{"zdb":["2615211-3"],"issn":["2045-2322"],"eki":["663366712"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 12.07.24"],"origin":[{"publisher":"Springer Nature ; Nature Publishing Group","dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisherPlace":"[London] ; London"}],"title":[{"title_sort":"Scientific reports","title":"Scientific reports"}]}]} | ||
| SRT | |a DAESCHLERSULTRASOUND1620 | ||