Intravitreal sustained-release steroid implants for the treatment of macular edema following surgical removal of epiretinal membranes

<b><i>Purpose:</i></b> To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. <b><i>Methods:</i></b> In this multicenter study, we retro...

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Main Authors:	Hattenbach, Lars-Olof (Author) , Springer-Wanner, Christina (Author) , Hoerauf, Hans (Author) , Callizo, Josep (Author) , Jungmann, Stephanie (Author) , Brauns, Thomas (Author) , Fulle, Gergana (Author) , Eichel, Sebastian (Author) , Koss, Michael Janusz (Author) , Kuhli-Hattenbach, Claudia (Author)
Format:	Article (Journal)
Language:	English
Published:	2017
In:	Ophthalmologica Year: 2017, Volume: 237, Issue: 4, Pages: 232-237
ISSN:	1423-0267
DOI:	10.1159/000464259
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1159/000464259 Verlag, Volltext: https://www.karger.com/Article/FullText/464259
Author Notes:	Lars-Olof Hattenbach, Christina Springer-Wanner, Hans Hoerauf, Josep Callizo, Stephanie Jungmann, Thomas Brauns, Gergana Fulle, Sebastian Eichel, Michael Janusz Koss, Claudia Kuhli-Hattenbach

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Summary:	<b><i>Purpose:</i></b> To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. <b><i>Methods:</i></b> In this multicenter study, we retrospectively reviewed the data of 37 patients (39 eyes) who had been treated with intravitreal dexamethasone implant (Ozurdex®) for persistent CME following macular pucker surgery. Main outcome measures were change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). <b><i>Results:</i></b> All eyes underwent spectral domain optical coherence tomography examination within 130 days after implantation. We observed a significant decrease in mean CRT from 519.9 to 392.9 µm (<i>p</i> < 0.0001). By this time, mean BCVA had improved from 0.60 to 0.43 logMAR (<i>p</i> = 0.003). Seventeen eyes (43.6%) required at least 1 repeat injection of dexamethasone. Of these, 8 (47%) eyes received a total number of 3 or more dexamethasone injections. <b><i>Conclusion:</i></b> Intravitreal dexamethasone implant injection is an effective treatment option for persistent CME following macular pucker surgery.
Item Description:	Gesehen am 11.09.2018
Physical Description:	Online Resource
ISSN:	1423-0267
DOI:	10.1159/000464259