Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration
Spatial molecular patterning enables the regulation of adhesion receptor clustering and can thus play a pivotal role in multiple biological activities such as cell adhesion, viability, proliferation, and differentiation. A wide range of nanopatterned, adhesive interfaces have been designed to deciph...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 July 2017
|
| In: |
ACS nano
Year: 2017, Jahrgang: 11, Heft: 8, Pages: 8282-8291 |
| ISSN: | 1936-086X |
| DOI: | 10.1021/acsnano.7b03449 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1021/acsnano.7b03449 Verlag, Volltext: https://doi.org/10.1021/acsnano.7b03449 
|
| Verfasserangaben: | Jie Deng, Changsheng Zhao, Joachim P. Spatz, and Qiang Wei |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 158090033X | ||
| 003 | DE-627 | ||
| 005 | 20220815010000.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180912s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acsnano.7b03449 |2 doi | |
| 035 | |a (DE-627)158090033X | ||
| 035 | |a (DE-576)51090033X | ||
| 035 | |a (DE-599)BSZ51090033X | ||
| 035 | |a (OCoLC)1341018407 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Deng, Jie |e VerfasserIn |0 (DE-588)1218264039 |0 (DE-627)1733701613 |4 aut | |
| 245 | 1 | 0 | |a Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration |c Jie Deng, Changsheng Zhao, Joachim P. Spatz, and Qiang Wei |
| 264 | 1 | |c 20 July 2017 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.09.2018 | ||
| 520 | |a Spatial molecular patterning enables the regulation of adhesion receptor clustering and can thus play a pivotal role in multiple biological activities such as cell adhesion, viability, proliferation, and differentiation. A wide range of nanopatterned, adhesive interfaces have been designed to decipher the essence of molecular-scale interactions between cells and the adhesive interface. Although an interligand spacing of less than 70 nm is a proven prerequisite for the formation of stable focal adhesions, there is a paucity of data concerning how cells behave on substrates featuring heterogeneous adhesiveness. In this study, a stretchable hydrogel functionalized with a quasi-hexagonally arranged nanoarray was stretched along one direction, resulting in ligands periodically arranged in a pattern resembling a centered rectangular lattice with an interligand spacing smaller than 70 nm in one direction and greater than 70 nm in the orthogonal direction. This substrate was utilized to modulate interligand spacing and investigate cell adhesion and migration. An interligand spacing larger than 70 nm—even in just one direction—prevented the establishment of stable focal adhesions. The stretched interface promoted dynamic remodeling at cell contacts, resulting in higher cellular mobility. Our nanopatterned stretchable hydrogel permits reversible control over cell adhesion and migration on nanopatterned ligand interfaces. | ||
| 700 | 1 | |a Spatz, Joachim P. |d 1969- |e VerfasserIn |0 (DE-588)122582675 |0 (DE-627)08203124X |0 (DE-576)173014771 |4 aut | |
| 700 | 1 | |a Wei, Qiang |e VerfasserIn |0 (DE-588)1137351764 |0 (DE-627)894512900 |0 (DE-576)491281552 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American Chemical Society |t ACS nano |d Washington, DC : Soc., 2007 |g 11(2017), 8, Seite 8282-8291 |h Online-Ressource |w (DE-627)539881392 |w (DE-600)2383064-5 |w (DE-576)276561139 |x 1936-086X |7 nnas |
| 773 | 1 | 8 | |g volume:11 |g year:2017 |g number:8 |g pages:8282-8291 |g extent:10 |a Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acsnano.7b03449 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1021/acsnano.7b03449 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180912 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1137351764 |a Wei, Qiang |m 1137351764:Wei, Qiang |d 120000 |d 120300 |e 120000PW1137351764 |e 120300PW1137351764 |k 0/120000/ |k 1/120000/120300/ |p 4 |y j | ||
| 998 | |g 122582675 |a Spatz, Joachim P. |m 122582675:Spatz, Joachim P. |d 120000 |d 120300 |d 700000 |d 718000 |e 120000PS122582675 |e 120300PS122582675 |e 700000PS122582675 |e 718000PS122582675 |k 0/120000/ |k 1/120000/120300/ |k 0/700000/ |k 1/700000/718000/ |p 3 | ||
| 999 | |a KXP-PPN158090033X |e 3025349972 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration","title":"Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration"}],"person":[{"role":"aut","display":"Deng, Jie","roleDisplay":"VerfasserIn","given":"Jie","family":"Deng"},{"family":"Spatz","given":"Joachim P.","roleDisplay":"VerfasserIn","display":"Spatz, Joachim P.","role":"aut"},{"family":"Wei","given":"Qiang","display":"Wei, Qiang","roleDisplay":"VerfasserIn","role":"aut"}],"note":["Gesehen am 12.09.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"158090033X","language":["eng"],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"20 July 2017"}],"id":{"doi":["10.1021/acsnano.7b03449"],"eki":["158090033X"]},"name":{"displayForm":["Jie Deng, Changsheng Zhao, Joachim P. Spatz, and Qiang Wei"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"id":{"issn":["1936-086X"],"eki":["539881392"],"zdb":["2383064-5"]},"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"2007-","dateIssuedKey":"2007","publisher":"Soc."}],"name":{"displayForm":["American Chemical Society"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"ACS nano","title_sort":"ACS nano"}],"part":{"year":"2017","issue":"8","pages":"8282-8291","text":"11(2017), 8, Seite 8282-8291","volume":"11","extent":"10"},"titleAlt":[{"title":"Nano"}],"pubHistory":["1.2007,Aug. -"],"recId":"539881392","corporate":[{"role":"aut","roleDisplay":"VerfasserIn","display":"American Chemical Society"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"American Chemical SocietyACS nano"}]} | ||
| SRT | |a DENGJIESPANANOPATTER2020 | ||